Linked Life Data

18370152

Source:http://linkedlifedata.com/resource/pubmed/id/18370152

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2008-3-28
pubmed:abstractText
Our understanding of virus control by natural killer (NK) cells relies mainly on in vitro observations. The significance of these findings for virus control in vivo is not yet fully understood. Complexity is added by the fact that many viruses, particularly herpesviruses, are equipped with sets of genes that, dependent on the genetic background of the host, modify the NK cell response. The advent of recombinant DNA technology and mutagenesis procedures for BAC-cloned viral genomes has made it possible not only to screen for viral proteins with such functions but also to assess their biological relevance. Mutant viruses with gene defects reveal the efficacy and complexity of NK cell control. Here, we describe procedures to assess the NK cell response to mouse cytomegalovirus (MCMV), a prominent virus model for studying NK cell functions in vivo.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
1064-3745
pubmed:author
pubmed:issnType
Print
pubmed:volume
415
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
127-49
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Dissection of the antiviral NK cell response by MCMV mutants.
pubmed:affiliation
Department of Histology and Embryology, Faculty of Medicine, University of Rijeka, Rijeka, Croatia.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't