| pubmed-article:18369625 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18369625 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:18369625 | lifeskim:mentions | umls-concept:C0038013 | lld:lifeskim |
| pubmed-article:18369625 | lifeskim:mentions | umls-concept:C0178719 | lld:lifeskim |
| pubmed-article:18369625 | lifeskim:mentions | umls-concept:C1367028 | lld:lifeskim |
| pubmed-article:18369625 | lifeskim:mentions | umls-concept:C0205148 | lld:lifeskim |
| pubmed-article:18369625 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:18369625 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:18369625 | pubmed:dateCreated | 2008-7-11 | lld:pubmed |
| pubmed-article:18369625 | pubmed:abstractText | Ankylosing spondylitis (AS) is characterized by ankylosis of axial joints but osteoporosis is also a well-reported feature. T cells have been implicated as a source of receptor activator of NFkappaB ligand (RANKL) in inflammatory bone diseases. Hence, we assessed whether T cells in patients with AS act as a source of RANKL too. Therefore, we investigated the expression of RANKL on T cells from 21 patients with AS by flow cytometry. Bone mineral density (BMD) was evaluated by quantitative computer tomography (QCT) and dual X-ray absorptiometry (DXA) and correlated with serum levels of osteoprotegerin (OPG) and RANKL. BMD was decreased in 45% of all patients when measured with DXA (48% with QCT) and correlated negatively with OPG. Expression of intracellular RANKL was increased on CD4+ (84 vs. 70%) and CD8+ (85.2 vs. 65.3%, P < 0.05) T cells in patients with AS, whereas expression of membrane-bound RANKL was significantly lower (CD4+: 2.2 vs. 8.5% and CD8+: 0.7 vs. 3.2%, P < 0.01). Our results indicate that surface and intracellular RANKL production is differentially regulated on T cells of patients with AS. | lld:pubmed |
| pubmed-article:18369625 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18369625 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369625 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18369625 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369625 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369625 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369625 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18369625 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18369625 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:18369625 | pubmed:issn | 0172-8172 | lld:pubmed |
| pubmed-article:18369625 | pubmed:author | pubmed-author:PietschmannPe... | lld:pubmed |
| pubmed-article:18369625 | pubmed:author | pubmed-author:ReschHeinrich... | lld:pubmed |
| pubmed-article:18369625 | pubmed:author | pubmed-author:RaunerMartina... | lld:pubmed |
| pubmed-article:18369625 | pubmed:author | pubmed-author:MuschitzChris... | lld:pubmed |
| pubmed-article:18369625 | pubmed:author | pubmed-author:PatschJaninaJ | lld:pubmed |
| pubmed-article:18369625 | pubmed:author | pubmed-author:StupphannDani... | lld:pubmed |
| pubmed-article:18369625 | pubmed:author | pubmed-author:KrenbekDagmar... | lld:pubmed |
| pubmed-article:18369625 | pubmed:author | pubmed-author:PirkerThomasT | lld:pubmed |
| pubmed-article:18369625 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18369625 | pubmed:volume | 28 | lld:pubmed |
| pubmed-article:18369625 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18369625 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18369625 | pubmed:pagination | 987-93 | lld:pubmed |
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| pubmed-article:18369625 | pubmed:meshHeading | pubmed-meshheading:18369625... | lld:pubmed |
| pubmed-article:18369625 | pubmed:meshHeading | pubmed-meshheading:18369625... | lld:pubmed |
| pubmed-article:18369625 | pubmed:meshHeading | pubmed-meshheading:18369625... | lld:pubmed |
| pubmed-article:18369625 | pubmed:meshHeading | pubmed-meshheading:18369625... | lld:pubmed |
| pubmed-article:18369625 | pubmed:meshHeading | pubmed-meshheading:18369625... | lld:pubmed |
| pubmed-article:18369625 | pubmed:meshHeading | pubmed-meshheading:18369625... | lld:pubmed |
| pubmed-article:18369625 | pubmed:meshHeading | pubmed-meshheading:18369625... | lld:pubmed |
| pubmed-article:18369625 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18369625 | pubmed:articleTitle | Intracellular and surface RANKL are differentially regulated in patients with ankylosing spondylitis. | lld:pubmed |
| pubmed-article:18369625 | pubmed:affiliation | Department of Pathophysiology, Center of Physiology and Pathophysiology, Medical University of Vienna, Vienna, Austria. daniela.stupphann@meduniwien.ac.at | lld:pubmed |
| pubmed-article:18369625 | pubmed:publicationType | Journal Article | lld:pubmed |
| entrez-gene:8600 | entrezgene:pubmed | pubmed-article:18369625 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:18369625 | lld:entrezgene |
| lhgdn:association:2687 | lhgdn:found_in | pubmed-article:18369625 | lld:lhgdn |
