| pubmed-article:18368410 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18368410 | lifeskim:mentions | umls-concept:C0295352 | lld:lifeskim |
| pubmed-article:18368410 | lifeskim:mentions | umls-concept:C1708300 | lld:lifeskim |
| pubmed-article:18368410 | lifeskim:mentions | umls-concept:C0224522 | lld:lifeskim |
| pubmed-article:18368410 | lifeskim:mentions | umls-concept:C0036751 | lld:lifeskim |
| pubmed-article:18368410 | lifeskim:mentions | umls-concept:C0040284 | lld:lifeskim |
| pubmed-article:18368410 | lifeskim:mentions | umls-concept:C1514559 | lld:lifeskim |
| pubmed-article:18368410 | lifeskim:mentions | umls-concept:C0012472 | lld:lifeskim |
| pubmed-article:18368410 | lifeskim:mentions | umls-concept:C1415809 | lld:lifeskim |
| pubmed-article:18368410 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:18368410 | lifeskim:mentions | umls-concept:C0449560 | lld:lifeskim |
| pubmed-article:18368410 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:18368410 | pubmed:dateCreated | 2008-7-11 | lld:pubmed |
| pubmed-article:18368410 | pubmed:abstractText | Serotonin antagonists show impressive analgesic efficacy in rheumatoid arthritis, osteoarthritis (OA) or fibromyalgia; however, this effect is not well understood. We examined the mechanism of serotonin-induced inflammation and its antagonists in OA. Serotonin receptor subtypes and COX-2 were analysed by RT-PCR from synovial tissue. Serum-free cultures were stimulated with 10 muM serotonin and/or the antagonists ketanserin (5-HT(2A)), tropisetron (5-HT(3)) and parecoxib (COX-2). Prostaglandin E(2) (PGE(2)), tumour necrosis factor alpha (TNF-alpha), interleukin 1beta (IL-1beta) and leukotriene B4 (LTB4) were measured by an immunoassay in the supernatants. RT-PCR results showed mRNA for 5-HT(2A) and 5-HT(3) receptors, and COX-2. PGE(2) in the supernatants increased by 261.2% +/- 56.7 (mean +/- SEM; P = 0.007) in response to serotonin. TNF-alpha, IL-1beta and LTB4 levels did not change. Ketanserin, tropisetron and parecoxib suppressed PGE(2). The serotonin-induced PGE(2) overexpression appeared thus to be mediated by 5-HT(2A) and 5-HT(3) receptors. This activation might involve COX-2. The findings may explain the potent benefit of 5-HT(3) antagonists. | lld:pubmed |
| pubmed-article:18368410 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18368410 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18368410 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18368410 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18368410 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18368410 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18368410 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18368410 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18368410 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18368410 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18368410 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18368410 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18368410 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18368410 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18368410 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18368410 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18368410 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18368410 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18368410 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18368410 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18368410 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18368410 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18368410 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:18368410 | pubmed:issn | 0172-8172 | lld:pubmed |
| pubmed-article:18368410 | pubmed:author | pubmed-author:VetterHansH | lld:pubmed |
| pubmed-article:18368410 | pubmed:author | pubmed-author:Candelario-Ja... | lld:pubmed |
| pubmed-article:18368410 | pubmed:author | pubmed-author:FiebichBernd... | lld:pubmed |
| pubmed-article:18368410 | pubmed:author | pubmed-author:Ulrich-Merzen... | lld:pubmed |
| pubmed-article:18368410 | pubmed:author | pubmed-author:SeidelMatthia... | lld:pubmed |
| pubmed-article:18368410 | pubmed:author | pubmed-author:KochFranz-Wal... | lld:pubmed |
| pubmed-article:18368410 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18368410 | pubmed:volume | 28 | lld:pubmed |
| pubmed-article:18368410 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18368410 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18368410 | pubmed:pagination | 1017-22 | lld:pubmed |
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| pubmed-article:18368410 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18368410 | pubmed:articleTitle | Serotonin mediates PGE2 overexpression through 5-HT2A and 5-HT3 receptor subtypes in serum-free tissue culture of macrophage-like synovial cells. | lld:pubmed |
| pubmed-article:18368410 | pubmed:affiliation | Rheumatology, Medizinische Universitäts-Poliklink, Bonn, Germany. Matthias.Seidel@ukb.uni-bonn.de | lld:pubmed |
| pubmed-article:18368410 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18368410 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:3356 | entrezgene:pubmed | pubmed-article:18368410 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:18368410 | lld:entrezgene |
