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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2008-4-18
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pubmed:abstractText |
The Azoospermia Factor c (AZFc) region of the human Y chromosome is a unique product of segmental duplication. It consists almost entirely of very long amplicons, represented by different colors, and is frequently deleted in subfertile men. Most of the AZFc amplicons have high sequence similarity with autosomal segments, indicating recent duplication and transposition to the Y chromosome. The Deleted in Azoospermia (DAZ) gene within the red-amplicon arose from an ancestral autosomal DAZ-like (DAZL) gene. It varies significantly between different men regarding to its copy number and the numbers of RNA recognition motif and DAZ repeat it encodes. We used Southern analyses to study the evolution of DAZ and AZFc amplicons on the Y chromosomes of primates.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18366765-10192397,
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2148
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
96
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:18366765-Animals,
pubmed-meshheading:18366765-Blotting, Southern,
pubmed-meshheading:18366765-Chromosomes, Human, Y,
pubmed-meshheading:18366765-Evolution, Molecular,
pubmed-meshheading:18366765-Gene Duplication,
pubmed-meshheading:18366765-Genetic Loci,
pubmed-meshheading:18366765-Humans,
pubmed-meshheading:18366765-Primates,
pubmed-meshheading:18366765-RNA-Binding Proteins,
pubmed-meshheading:18366765-Seminal Plasma Proteins,
pubmed-meshheading:18366765-Y Chromosome
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pubmed:year |
2008
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pubmed:articleTitle |
Evolution of the DAZ gene and the AZFc region on primate Y chromosomes.
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pubmed:affiliation |
Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan. allenjohnyu@msn.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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