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rdf:type |
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lifeskim:mentions |
umls-concept:C0007586,
umls-concept:C0007600,
umls-concept:C0072522,
umls-concept:C0205263,
umls-concept:C0237477,
umls-concept:C0431085,
umls-concept:C0441655,
umls-concept:C1326205,
umls-concept:C1511636,
umls-concept:C1527392,
umls-concept:C1533691
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pubmed:dateCreated |
2008-4-10
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pubmed:abstractText |
Protein-bound polysaccharide (PSK) is derived from the CM-101 strain of the fungus Coriolus versicolor and has shown anticancer activity in vitro and in in vivo experimental models and human cancers. Several randomized clinical trials have demonstrated that PSK has great potential in adjuvant cancer therapy, with positive results in the adjuvant treatment of gastric, esophageal, colorectal, breast and lung cancers. These studies have suggested the efficacy of PSK as an immunomodulator of biological responses. The precise molecular mechanisms responsible for its biological activity have yet to be fully elucidated.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18366723-10374675,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18366723-10702635,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18366723-10784373,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18366723-10952028,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18366723-11358267,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18366723-11459171,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18366723-12168863,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18366723-12436306,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18366723-12536241,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18366723-12687011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18366723-1372283,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18366723-14499133,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18366723-14767513,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18366723-14997197,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18366723-15183847,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18366723-15602655,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18366723-15726350,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18366723-16133112,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18366723-16525672,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18366723-16677386,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18366723-16803844,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18366723-17106715,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18366723-17419278,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18366723-17764620,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18366723-6238674,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18366723-7606203,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18366723-7910230,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18366723-8599969,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18366723-8830763,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18366723-9064481,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18366723-9505208
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2407
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
78
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:18366723-Animals,
pubmed-meshheading:18366723-Apoptosis,
pubmed-meshheading:18366723-Cell Cycle,
pubmed-meshheading:18366723-Cell Line, Tumor,
pubmed-meshheading:18366723-Cell Proliferation,
pubmed-meshheading:18366723-Drug Screening Assays, Antitumor,
pubmed-meshheading:18366723-Fungal Proteins,
pubmed-meshheading:18366723-Fungi,
pubmed-meshheading:18366723-HeLa Cells,
pubmed-meshheading:18366723-Humans,
pubmed-meshheading:18366723-Immunologic Factors,
pubmed-meshheading:18366723-Jurkat Cells,
pubmed-meshheading:18366723-Lymphocytes,
pubmed-meshheading:18366723-Melanoma, Experimental,
pubmed-meshheading:18366723-Mice,
pubmed-meshheading:18366723-Polysaccharides,
pubmed-meshheading:18366723-Proteoglycans
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pubmed:year |
2008
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pubmed:articleTitle |
The immunomodulator PSK induces in vitro cytotoxic activity in tumour cell lines via arrest of cell cycle and induction of apoptosis.
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pubmed:affiliation |
Servicio de Análisis Clínicos e Inmunologia, Hospital Universitario Virgen de las Nieves, Universidad de Granada, Av, de las Fuerzas Armadas 2, 18014 Granada, Spain. evajimenez@fundacionhvn.org
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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