pubmed-article:18366722 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:18366722 | lifeskim:mentions | umls-concept:C0025663 | lld:lifeskim |
pubmed-article:18366722 | lifeskim:mentions | umls-concept:C0020205 | lld:lifeskim |
pubmed-article:18366722 | lifeskim:mentions | umls-concept:C0205246 | lld:lifeskim |
pubmed-article:18366722 | lifeskim:mentions | umls-concept:C0679199 | lld:lifeskim |
pubmed-article:18366722 | lifeskim:mentions | umls-concept:C0681916 | lld:lifeskim |
pubmed-article:18366722 | lifeskim:mentions | umls-concept:C0750572 | lld:lifeskim |
pubmed-article:18366722 | lifeskim:mentions | umls-concept:C0680844 | lld:lifeskim |
pubmed-article:18366722 | lifeskim:mentions | umls-concept:C0549193 | lld:lifeskim |
pubmed-article:18366722 | lifeskim:mentions | umls-concept:C2698650 | lld:lifeskim |
pubmed-article:18366722 | pubmed:dateCreated | 2008-4-8 | lld:pubmed |
pubmed-article:18366722 | pubmed:abstractText | Modeling and simulation of cellular signaling and metabolic pathways as networks of biochemical reactions yields sets of non-linear ordinary differential equations. These models usually depend on several parameters and initial conditions. If these parameters are unknown, results from simulation studies can be misleading. Such a scenario can be avoided by fitting the model to experimental data before analyzing the system. This involves parameter estimation which is usually performed by minimizing a cost function which quantifies the difference between model predictions and measurements. Mathematically, this is formulated as a non-linear optimization problem which often results to be multi-modal (non-convex), rendering local optimization methods detrimental. | lld:pubmed |
pubmed-article:18366722 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18366722 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18366722 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18366722 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18366722 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18366722 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18366722 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18366722 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18366722 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18366722 | pubmed:language | eng | lld:pubmed |
pubmed-article:18366722 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18366722 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:18366722 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:18366722 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:18366722 | pubmed:issn | 1752-0509 | lld:pubmed |
pubmed-article:18366722 | pubmed:author | pubmed-author:FleckChristia... | lld:pubmed |
pubmed-article:18366722 | pubmed:author | pubmed-author:TimmerJensJ | lld:pubmed |
pubmed-article:18366722 | pubmed:author | pubmed-author:BangaJulio... | lld:pubmed |
pubmed-article:18366722 | pubmed:author | pubmed-author:Balsa-CantoEv... | lld:pubmed |
pubmed-article:18366722 | pubmed:author | pubmed-author:PeiferMartinM | lld:pubmed |
pubmed-article:18366722 | pubmed:issnType | Electronic | lld:pubmed |
pubmed-article:18366722 | pubmed:volume | 2 | lld:pubmed |
pubmed-article:18366722 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:18366722 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:18366722 | pubmed:pagination | 26 | lld:pubmed |
pubmed-article:18366722 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
pubmed-article:18366722 | pubmed:meshHeading | pubmed-meshheading:18366722... | lld:pubmed |
pubmed-article:18366722 | pubmed:meshHeading | pubmed-meshheading:18366722... | lld:pubmed |
pubmed-article:18366722 | pubmed:meshHeading | pubmed-meshheading:18366722... | lld:pubmed |
pubmed-article:18366722 | pubmed:meshHeading | pubmed-meshheading:18366722... | lld:pubmed |
pubmed-article:18366722 | pubmed:meshHeading | pubmed-meshheading:18366722... | lld:pubmed |
pubmed-article:18366722 | pubmed:meshHeading | pubmed-meshheading:18366722... | lld:pubmed |
pubmed-article:18366722 | pubmed:meshHeading | pubmed-meshheading:18366722... | lld:pubmed |
pubmed-article:18366722 | pubmed:meshHeading | pubmed-meshheading:18366722... | lld:pubmed |
pubmed-article:18366722 | pubmed:meshHeading | pubmed-meshheading:18366722... | lld:pubmed |
pubmed-article:18366722 | pubmed:meshHeading | pubmed-meshheading:18366722... | lld:pubmed |
pubmed-article:18366722 | pubmed:meshHeading | pubmed-meshheading:18366722... | lld:pubmed |
pubmed-article:18366722 | pubmed:meshHeading | pubmed-meshheading:18366722... | lld:pubmed |
pubmed-article:18366722 | pubmed:meshHeading | pubmed-meshheading:18366722... | lld:pubmed |
pubmed-article:18366722 | pubmed:year | 2008 | lld:pubmed |
pubmed-article:18366722 | pubmed:articleTitle | Hybrid optimization method with general switching strategy for parameter estimation. | lld:pubmed |
pubmed-article:18366722 | pubmed:affiliation | Process Engineering Group, Spanish Council for Scientific Research, IIM-CSIC, Spain. ebalsa@iim.csic.es | lld:pubmed |
pubmed-article:18366722 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:18366722 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18366722 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18366722 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18366722 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18366722 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18366722 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18366722 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18366722 | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18366722 | lld:pubmed |