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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2008-7-2
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pubmed:databankReference |
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pubmed:abstractText |
Carbohydrate counting is an effective approach to mealtime insulin adjustment in type 1 diabetes but has not been rigorously assessed in type 2 diabetes. We sought to compare an insulin-to-carbohydrate ratio with a simple algorithm for adjusting the dose of prandial insulin glusiline. RESEARCH AND DESIGN METHODS: This 24-week, multicenter, randomized, controlled study compared two algorithms for adjusting mealtime (glulisine) insulin along with a standard algorithm for adjusting background (glargine) insulin in 273 intent-to-treat patients with type 2 diabetes. Glulisine and glargine were adjusted weekly in both groups based on self-monitored blood glucose (SMBG) results from the previous week. The simple algorithm group was provided set doses of glulisine to take before each meal. The carbohydrate counting (carb count) group was provided an insulin-to-carbohydrate ratio to use for each meal and adjusted their glulisine dose based on the amount of carbohydrate consumed.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18364392-10480766,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18364392-11092290,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18364392-11225745,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18364392-11815505,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18364392-12361817,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18364392-12364302,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18364392-12716828,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18364392-12828818,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18364392-15008828,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18364392-15451901,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18364392-15616004,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18364392-15642078,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18364392-16004665,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18364392-16033730,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18364392-16308840,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18364392-16373931,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18364392-17934150,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18364392-18594065,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18364392-7587918,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18364392-8147960,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18364392-8366922,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18364392-9742976
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Dietary Carbohydrates,
http://linkedlifedata.com/resource/pubmed/chemical/Hemoglobin A, Glycosylated,
http://linkedlifedata.com/resource/pubmed/chemical/Hypoglycemic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin, Long-Acting,
http://linkedlifedata.com/resource/pubmed/chemical/Metformin,
http://linkedlifedata.com/resource/pubmed/chemical/glargine,
http://linkedlifedata.com/resource/pubmed/chemical/insulin glulisine
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1935-5548
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1305-10
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:18364392-Adult,
pubmed-meshheading:18364392-Aged,
pubmed-meshheading:18364392-Algorithms,
pubmed-meshheading:18364392-Blood Glucose,
pubmed-meshheading:18364392-Continental Population Groups,
pubmed-meshheading:18364392-Diabetes Mellitus, Type 2,
pubmed-meshheading:18364392-Dietary Carbohydrates,
pubmed-meshheading:18364392-Dose-Response Relationship, Drug,
pubmed-meshheading:18364392-Drug Administration Schedule,
pubmed-meshheading:18364392-Eating,
pubmed-meshheading:18364392-Female,
pubmed-meshheading:18364392-Hemoglobin A, Glycosylated,
pubmed-meshheading:18364392-Humans,
pubmed-meshheading:18364392-Hypoglycemic Agents,
pubmed-meshheading:18364392-Insulin,
pubmed-meshheading:18364392-Insulin, Long-Acting,
pubmed-meshheading:18364392-Male,
pubmed-meshheading:18364392-Metformin,
pubmed-meshheading:18364392-Middle Aged,
pubmed-meshheading:18364392-United States
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pubmed:year |
2008
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pubmed:articleTitle |
Adjust to target in type 2 diabetes: comparison of a simple algorithm with carbohydrate counting for adjustment of mealtime insulin glulisine.
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pubmed:affiliation |
International Diabetes Center at Park Nicollet, Minneapolis, Minnesota, USA. richard.bergenstal@parknicollet.com
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Multicenter Study
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