|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
10
|
|
pubmed:dateCreated |
2008-10-20
|
|
pubmed:abstractText |
A series of novel pyrrolidine derivatives were designed, synthesized and assayed for their inhibitory activities on matrix metalloproteinase 2 (MMP-2) and aminopeptidase N (AP-N). The results showed that these pyrrolidine derivatives exhibited highly selective inhibition against MMP-2 as compared with AP-N. The hydroxamates 8a-c were equally or more potent MMP-2 inhibitors than the positive control LY52. The binding mode of the most potent compound 8a with MMP-2 was proposed. Structure-activity relationships were also briefly discussed.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
0223-5234
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
43
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2130-9
|
|
pubmed:meshHeading |
pubmed-meshheading:18362041-Amino Acid Sequence,
pubmed-meshheading:18362041-Antigens, CD13,
pubmed-meshheading:18362041-Drug Design,
pubmed-meshheading:18362041-Enzyme Inhibitors,
pubmed-meshheading:18362041-Matrix Metalloproteinase 2,
pubmed-meshheading:18362041-Matrix Metalloproteinases,
pubmed-meshheading:18362041-Models, Molecular,
pubmed-meshheading:18362041-Molecular Conformation,
pubmed-meshheading:18362041-Pyrrolidines
|
|
pubmed:year |
2008
|
|
pubmed:articleTitle |
Design, synthesis and preliminary evaluation of novel pyrrolidine derivatives as matrix metalloproteinase inhibitors.
|
|
pubmed:affiliation |
Institute of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, No. 44 Wenhuaxi Road, Jinan 250012, China. chengxianchao2000@yahoo.com.cn
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
