|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0012655,
umls-concept:C0017431,
umls-concept:C0019169,
umls-concept:C0030705,
umls-concept:C0205466,
umls-concept:C0439849,
umls-concept:C0683598,
umls-concept:C0871261,
umls-concept:C0971023,
umls-concept:C1456348,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
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|
pubmed:issue |
6
|
|
pubmed:dateCreated |
2008-5-12
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|
pubmed:abstractText |
The efficacy of anti-viral therapy for chronic hepatitis B virus (HBV) is lost upon the emergence of resistant virus. Using >500 patient HBV isolates from several entecavir clinical trials, we show that phenotypic susceptibility correlates with genotypic resistance and patient virologic responses.
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|
pubmed:commentsCorrections |
|
|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
0168-8278
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
48
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
895-902
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|
pubmed:meshHeading |
pubmed-meshheading:18362040-Antiviral Agents,
pubmed-meshheading:18362040-DNA, Viral,
pubmed-meshheading:18362040-Drug Monitoring,
pubmed-meshheading:18362040-Drug Resistance, Viral,
pubmed-meshheading:18362040-Genetic Predisposition to Disease,
pubmed-meshheading:18362040-Genotype,
pubmed-meshheading:18362040-Guanine,
pubmed-meshheading:18362040-Hepatitis B,
pubmed-meshheading:18362040-Hepatitis B virus,
pubmed-meshheading:18362040-Humans,
pubmed-meshheading:18362040-Lamivudine,
pubmed-meshheading:18362040-Longitudinal Studies,
pubmed-meshheading:18362040-Mutation,
pubmed-meshheading:18362040-Phenotype
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|
pubmed:year |
2008
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|
pubmed:articleTitle |
Hepatitis B virus quasispecies susceptibility to entecavir confirms the relationship between genotypic resistance and patient virologic response.
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|
pubmed:affiliation |
Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, CT 06492, USA. joe.baldick@bms.com
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pubmed:publicationType |
Journal Article
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