Linked Life Data

18361734

Source:http://linkedlifedata.com/resource/pubmed/id/18361734

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2008-3-25
pubmed:abstractText
Peroxynitrite (ONOO(-)) is a reactive oxidant formed from superoxide and nitric oxide that can readily oxidize cellular components, including essential protein, non-protein thiols, and DNA. ONOO(-) has contributed to the pathogenesis of diseases such as stroke, heart disease, Alzheimer's disease, and atherosclerosis. In this study, the ability of dimethyl lithospermate (DML), isolated from Salvia miltiorrhiza, to scavenge ONOO(-) and to protect cells against reactive species and ONOO(-) was investigated. The data obtained show that DML can efficiently scavenge native ONOO(-) as well as ONOO(-) derived from the ONOO(-) donor 3-morpholinosydnonimine hydrochloride. Spectrophotometric analysis revealed that DML led to decreased ONOO(-)-mediated nitration of tyrosine through electron donation. DML significantly inhibited nitration of bovine serum albumin by ONOO(-) in a dose-dependent manner. DML also manifested cytoprotection from cell damage induced by ONOO(-). The present study suggests that DML is an effective ONOO(-) scavenger and promotes cellular defense activity in the protection against ONOO(-)-involved diseases.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1096-620X
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
21-8
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Antioxidant potential of dimethyl lithospermate isolated from Salvia miltiorrhiza (red sage) against peroxynitrite.
pubmed:affiliation
College of Pharmacy, Aging Tissue Bank, Pusan National University, Busan, Republic of Korea.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't