Source:http://linkedlifedata.com/resource/pubmed/id/18360020
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2008-3-24
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| pubmed:abstractText |
Age-related decline of plasma dehydroepiandrosterone-sulfate (DHEA-S) levels may be associated with the risk of cardiovascular disease in women. We investigated whether plasma DHEA-S levels are related to endothelial function in postmenopausal women with coronary risk factors. One hundred and fifteen postmenopausal women (mean age+/-SD: 57+/-5 years; range: 48-65 years) who underwent measurement of flow-mediated vasodilation (FMD) of the brachial artery using ultrasonography were enrolled. Plasma hormone levels were determined in the morning after a 14-h fast, and the relationship between hormone levels and FMD was analyzed. DHEA-S was significantly correlated with %FMD (r=0.392, p<0.001), while estradiol, total testosterone and cortisol were not. %FMD in the highest quartile of DHEA-S was 1.8-fold higher than that in the lowest quartile (5.3+/-1.3 vs. 2.9+/-2.0 [means+/-SD], p<0.01). Multiple regression analysis revealed that DHEA-S was related to %FMD independent of age, body mass index, hypertension, hyperlipidemia, diabetes mellitus and smoking (beta=0.344, p<0.01), and was itself independent of age, body mass index, systolic blood pressure, total cholesterol, high-density lipoprotein (HDL) cholesterol, fasting plasma glucose and smoking (beta=0.291, p<0.05). In conclusion, plasma DHEA-S levels were weakly but significantly related to endothelial function in postmenopausal women independent of other coronary risk factors, suggesting a protective effect of DHEA on the endothelium.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
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| pubmed:issn |
0916-9636
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
31
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
69-74
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| pubmed:meshHeading |
pubmed-meshheading:18360020-Aged,
pubmed-meshheading:18360020-Aging,
pubmed-meshheading:18360020-Biological Markers,
pubmed-meshheading:18360020-Brachial Artery,
pubmed-meshheading:18360020-Coronary Disease,
pubmed-meshheading:18360020-Cross-Sectional Studies,
pubmed-meshheading:18360020-Data Collection,
pubmed-meshheading:18360020-Data Interpretation, Statistical,
pubmed-meshheading:18360020-Dehydroepiandrosterone Sulfate,
pubmed-meshheading:18360020-Endothelium, Vascular,
pubmed-meshheading:18360020-Female,
pubmed-meshheading:18360020-Gonadal Steroid Hormones,
pubmed-meshheading:18360020-Humans,
pubmed-meshheading:18360020-Male,
pubmed-meshheading:18360020-Middle Aged,
pubmed-meshheading:18360020-Muscle, Smooth, Vascular,
pubmed-meshheading:18360020-Postmenopause,
pubmed-meshheading:18360020-Risk Factors
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| pubmed:year |
2008
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| pubmed:articleTitle |
Association of plasma dehydroepiandrosterone-sulfate levels with endothelial function in postmenopausal women with coronary risk factors.
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| pubmed:affiliation |
Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Japan. akishita-tky@umin.ac.jp
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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