Source:http://linkedlifedata.com/resource/pubmed/id/18359898
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
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| pubmed:dateCreated |
2008-5-7
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| pubmed:abstractText |
Identification of angiotensin-(1-12) as an intermediate precursor derived directly from angiotensinogen led us to explore whether the heart has the capacity to process angiotensin-(1-12) into biologically active angiotensin peptides. The generation of angiotensin I, angiotensin II, and angiotensin-(1-7) from exogenous angiotensin-(1-12) was evaluated in the effluent of isolated perfused hearts mounted on a Langendorff apparatus in three normotensive and two hypertensive strains: Sprague-Dawley, Lewis, congenic mRen2.Lewis, Wistar-Kyoto, and spontaneously hypertensive rats. Hearts were perfused with Krebs solution for 60 min before and after the addition of angiotensin-(1-12) (10 nmol/l). Angiotensin-(1-12) caused the rapid appearance of both angiotensin I and angiotensin II in the perfusate that peaked between 30 and 60 min of recirculation. Production of angiotensin-(1-7) from exogenous angiotensin-(1-12) rose steadily over the course of the 60-min experiment. These data directly demonstrate that angiotensin-(1-12) is a substrate for the formation of angiotensin peptides in cardiac tissue. This finding further suggests that this angiotensinogen-derived product is a previously unrecognized important precursor peptide to the renin-angiotensin system cascade.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin I,
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin II,
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensinogen,
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensins,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Ren2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Renin,
http://linkedlifedata.com/resource/pubmed/chemical/angiotensin I (1-7),
http://linkedlifedata.com/resource/pubmed/chemical/proangiotensin-12, rat
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| pubmed:status |
MEDLINE
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| pubmed:month |
May
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| pubmed:issn |
0363-6135
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
294
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
H2242-7
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| pubmed:meshHeading |
pubmed-meshheading:18359898-Angiotensin I,
pubmed-meshheading:18359898-Angiotensin II,
pubmed-meshheading:18359898-Angiotensinogen,
pubmed-meshheading:18359898-Angiotensins,
pubmed-meshheading:18359898-Animals,
pubmed-meshheading:18359898-Animals, Genetically Modified,
pubmed-meshheading:18359898-Disease Models, Animal,
pubmed-meshheading:18359898-Hypertension,
pubmed-meshheading:18359898-Male,
pubmed-meshheading:18359898-Myocardium,
pubmed-meshheading:18359898-Peptide Fragments,
pubmed-meshheading:18359898-Perfusion,
pubmed-meshheading:18359898-Rats,
pubmed-meshheading:18359898-Rats, Inbred Lew,
pubmed-meshheading:18359898-Rats, Inbred SHR,
pubmed-meshheading:18359898-Rats, Inbred WKY,
pubmed-meshheading:18359898-Rats, Sprague-Dawley,
pubmed-meshheading:18359898-Renin,
pubmed-meshheading:18359898-Renin-Angiotensin System,
pubmed-meshheading:18359898-Time Factors
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| pubmed:year |
2008
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| pubmed:articleTitle |
Angiotensin-(1-12) is an alternate substrate for angiotensin peptide production in the heart.
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| pubmed:affiliation |
Hypertension and Vascular Research Center, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA. atrask@wfubmc.edu).
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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