18359633

Source:http://linkedlifedata.com/resource/pubmed/id/18359633

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0003385, umls-concept:C0024117, umls-concept:C0087111, umls-concept:C0243072
pubmed:issue	8
pubmed:dateCreated	2008-4-15
pubmed:abstractText	SAR around alkyne-quinuclidine derivatives allowed the discovery of highly potent muscarinic antagonists displaying interesting preferential slow off-rates from the M3 receptor.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9107377
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Alkynes, http://linkedlifedata.com/resource/pubmed/chemical/Cholinergic Antagonists, http://linkedlifedata.com/resource/pubmed/chemical/Muscarinic Antagonists, http://linkedlifedata.com/resource/pubmed/chemical/Quinuclidines, http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Muscarinic M2, http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Muscarinic M3
pubmed:status	MEDLINE
pubmed:month	Apr
pubmed:issn	1464-3405
pubmed:author	pubmed-author:ChristopheBernardB, pubmed-author:GillardMichelM, pubmed-author:GuyauxMichelM, pubmed-author:JadotSophieS, pubmed-author:Lo BruttoPatrickP, pubmed-author:ProvinsLaurentL, pubmed-author:QuéréLucL, pubmed-author:StarckJean-PhilippeJP, pubmed-author:TalagaPatriceP
pubmed:issnType	Electronic
pubmed:day	15
pubmed:volume	18
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	2675-8
pubmed:meshHeading	pubmed-meshheading:18359633-Alkynes, pubmed-meshheading:18359633-Cholinergic Antagonists, pubmed-meshheading:18359633-Molecular Structure, pubmed-meshheading:18359633-Muscarinic Antagonists, pubmed-meshheading:18359633-Pulmonary Disease, Chronic Obstructive, pubmed-meshheading:18359633-Quinuclidines, pubmed-meshheading:18359633-Receptor, Muscarinic M2, pubmed-meshheading:18359633-Receptor, Muscarinic M3, pubmed-meshheading:18359633-Structure-Activity Relationship
pubmed:year	2008
pubmed:articleTitle	Alkyne-quinuclidine derivatives as potent and selective muscarinic antagonists for the treatment of COPD.
pubmed:affiliation	UCB, R&D, Chemin du Foriest, B-1420 Braine-L'Alleud, Belgium.
pubmed:publicationType	Journal Article