Source:http://linkedlifedata.com/resource/pubmed/id/18359322
Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
7
|
pubmed:dateCreated |
2008-3-24
|
pubmed:abstractText |
Although low-density lipoprotein cholesterol (LDL-C) is a well-established atherogenic factor for coronary heart disease, it does not completely represent the risk associated with atherogenic lipoproteins in the presence of high triglyceride (TG) levels. Constituent lipoproteins constituting non-high-density lipoprotein cholesterol (non-HDL-C) include atherogenic TG-rich lipoproteins, cholesteryl ester-enriched remnants of TG-rich lipoproteins, and lipoprotein(a). Recent observational and intervention studies suggest that the predictive value of non-HDL-C for cardiovascular risk and mortality is better than low-density lipoprotein cholesterol and that non-HDL-C correlates highly with plasma apolipoprotein B levels. Currently, the National Cholesterol Education Program Adult Treatment Panel III guidelines identify non-HDL-C as a secondary target of therapy in patients with TG elevation (> or =200 mg/dl) after the attainment of LDL-C target goals. In patients with coronary heart disease or coronary heart disease risk equivalents, an optional non-HDL-C goal is <100 mg/dl. To achieve the non-HDL-C goal, statin therapy may be intensified or combined with ezetimibe, niacin, a fibrate, or omega-3 fatty acids. In conclusion, non-HDL-C remains an important target of therapy for patients with elevated TGs, although its widespread adoption has yet to gain a foothold among health care professionals treating patients with dyslipidemia.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
AIM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Apr
|
pubmed:issn |
0002-9149
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
1
|
pubmed:volume |
101
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1003-8
|
pubmed:meshHeading |
pubmed-meshheading:18359322-Apolipoproteins B,
pubmed-meshheading:18359322-Atherosclerosis,
pubmed-meshheading:18359322-Cholesterol, LDL,
pubmed-meshheading:18359322-Coronary Disease,
pubmed-meshheading:18359322-Dyslipidemias,
pubmed-meshheading:18359322-Humans,
pubmed-meshheading:18359322-Predictive Value of Tests,
pubmed-meshheading:18359322-Triglycerides
|
pubmed:year |
2008
|
pubmed:articleTitle |
Relative atherogenicity and predictive value of non-high-density lipoprotein cholesterol for coronary heart disease.
|
pubmed:affiliation |
Division of Cardiology, University of Maryland Medical Center, Baltimore, MD, USA. mmiller@medicine.umaryland.edu <mmiller@medicine.umaryland.edu>
|
pubmed:publicationType |
Journal Article,
Review
|