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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
17
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pubmed:dateCreated |
2008-4-15
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pubmed:abstractText |
Diamond-like carbon (DLC) has been explored as a biomaterial with potential use for coating implantable devices and surgical instruments. In this study the interaction of DLC with mammalian neuronal cells has been studied along with its modifications to improve its function as a biomaterial. We describe the use of DLC, oxidised DLC and phosphorus-doped DLC to support the growth and survival of primary central nervous system neurones and neuroblastoma cells. None of these substrates were cytotoxic and primary neurones adhered better to phosphorus-doped DLC than unmodified DLC. This property was used to culture cortical neurones in a predetermined micropattern. This raises the potential of DLC as a biomaterial for central nervous system (CNS) implantation. Furthermore, patterned DLC and phosphorus-doped DLC can direct neuronal growth, generating a powerful tool to study neuronal networks in a spatially distinct way. This study reports the generation of nerve cell patterns via patterned deposition of DLC.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Biocompatible Materials,
http://linkedlifedata.com/resource/pubmed/chemical/Carbon,
http://linkedlifedata.com/resource/pubmed/chemical/Coated Materials, Biocompatible,
http://linkedlifedata.com/resource/pubmed/chemical/Diamond,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphorus,
http://linkedlifedata.com/resource/pubmed/chemical/Polylysine,
http://linkedlifedata.com/resource/pubmed/chemical/Polystyrenes,
http://linkedlifedata.com/resource/pubmed/chemical/Tetrazolium Salts,
http://linkedlifedata.com/resource/pubmed/chemical/Thiazoles,
http://linkedlifedata.com/resource/pubmed/chemical/thiazolyl blue
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0142-9612
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2573-80
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pubmed:meshHeading |
pubmed-meshheading:18359076-Animals,
pubmed-meshheading:18359076-Biocompatible Materials,
pubmed-meshheading:18359076-Carbon,
pubmed-meshheading:18359076-Cell Adhesion,
pubmed-meshheading:18359076-Cell Culture Techniques,
pubmed-meshheading:18359076-Cell Line, Tumor,
pubmed-meshheading:18359076-Cells, Cultured,
pubmed-meshheading:18359076-Cerebral Cortex,
pubmed-meshheading:18359076-Coated Materials, Biocompatible,
pubmed-meshheading:18359076-Diamond,
pubmed-meshheading:18359076-Embryo, Mammalian,
pubmed-meshheading:18359076-Mice,
pubmed-meshheading:18359076-Neuroblastoma,
pubmed-meshheading:18359076-Neurons,
pubmed-meshheading:18359076-Oxidation-Reduction,
pubmed-meshheading:18359076-Phosphorus,
pubmed-meshheading:18359076-Polylysine,
pubmed-meshheading:18359076-Polystyrenes,
pubmed-meshheading:18359076-Rats,
pubmed-meshheading:18359076-Rats, Wistar,
pubmed-meshheading:18359076-Spectrum Analysis, Raman,
pubmed-meshheading:18359076-Substrate Specificity,
pubmed-meshheading:18359076-Tetrazolium Salts,
pubmed-meshheading:18359076-Thiazoles
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pubmed:year |
2008
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pubmed:articleTitle |
Patterned growth of neuronal cells on modified diamond-like carbon substrates.
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pubmed:affiliation |
Henry Wellcome L.I.N.E., Clinical Sciences South Bristol, University of Bristol, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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