rdf:type |
|
lifeskim:mentions |
umls-concept:C0006675,
umls-concept:C0018338,
umls-concept:C0034493,
umls-concept:C0175727,
umls-concept:C0205217,
umls-concept:C0220781,
umls-concept:C0332206,
umls-concept:C0441655,
umls-concept:C0447590,
umls-concept:C0458451,
umls-concept:C0965412,
umls-concept:C1097411,
umls-concept:C1550548,
umls-concept:C1551359,
umls-concept:C1555714,
umls-concept:C1705654,
umls-concept:C1883254
|
pubmed:issue |
3
|
pubmed:dateCreated |
2008-9-2
|
pubmed:abstractText |
To study the direct relaxant activity of 5-cyclopropyl-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-4-ylamine (BAY 41-2272) in the rabbit penile urethra and to investigate its modulatory effect on nitric oxide (NO)-mediated responses.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3-(4-Amino-5-cyclopropylpyrimidine-2...,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic GMP,
http://linkedlifedata.com/resource/pubmed/chemical/Guanylate Cyclase,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Pyridines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cytoplasmic and Nuclear,
http://linkedlifedata.com/resource/pubmed/chemical/soluble guanylyl cyclase
|
pubmed:status |
MEDLINE
|
pubmed:month |
Sep
|
pubmed:issn |
1527-9995
|
pubmed:author |
|
pubmed:issnType |
Electronic
|
pubmed:volume |
72
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
711-5
|
pubmed:meshHeading |
pubmed-meshheading:18359064-Animals,
pubmed-meshheading:18359064-Calcium,
pubmed-meshheading:18359064-Cyclic GMP,
pubmed-meshheading:18359064-Guanylate Cyclase,
pubmed-meshheading:18359064-Male,
pubmed-meshheading:18359064-Models, Biological,
pubmed-meshheading:18359064-Muscle, Smooth,
pubmed-meshheading:18359064-Nitric Oxide,
pubmed-meshheading:18359064-Penis,
pubmed-meshheading:18359064-Potassium,
pubmed-meshheading:18359064-Pyrazoles,
pubmed-meshheading:18359064-Pyridines,
pubmed-meshheading:18359064-Rabbits,
pubmed-meshheading:18359064-Receptors, Cytoplasmic and Nuclear,
pubmed-meshheading:18359064-Signal Transduction,
pubmed-meshheading:18359064-Urinary Bladder
|
pubmed:year |
2008
|
pubmed:articleTitle |
Increased cyclic guanosine monophosphate synthesis and calcium entry blockade account for the relaxant activity of the nitric oxide-independent soluble guanylyl cyclase stimulator BAY 41-2272 in the rabbit penile urethra.
|
pubmed:affiliation |
Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|