Linked Life Data

18358332

Source:http://linkedlifedata.com/resource/pubmed/id/18358332

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2008-3-24
pubmed:abstractText
Admixture mapping, or mapping by admixture linkage disequilibrium, is a disease mapping strategy that has gained considerable popularity in recent years. It exploits the long-range linkage disequilibrium generated by admixture between genetically distinct ancestral populations. Compared to case-control association designs, admixture mapping requires fewer markers, and is more robust to allelic heterogeneity. At the same time, admixture mapping can be more powerful, and can achieve higher mapping resolution than traditional linkage studies, provided that the underlying trait variants occur at sufficiently different frequencies in the ancestral populations. In this chapter, we describe the recent methodology and software development, review successful applications, and comment on the future of this approach.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0065-2660
pubmed:author
pubmed:issnType
Print
pubmed:volume
60
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
547-69
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Admixture mapping and the role of population structure for localizing disease genes.
pubmed:affiliation
Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA.
pubmed:publicationType
Journal Article, Review, Research Support, N.I.H., Extramural