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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
23
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pubmed:dateCreated |
1992-1-9
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pubmed:abstractText |
While alpha beta T cells in mammals may express one of many variable (V) gene families in the beta locus, chickens have only two V beta gene families. The avian V beta 2+ T cells are recognized by the T-cell receptor 3 (TCR3) monoclonal antibody and V beta 1+ T cells are recognized by the TCR2 antibody, which we used to selectively suppress development of V beta 1+ T cells in order to examine their functional role. Suppression was accomplished by multiple injections of anti-TCR2 antibodies beginning in embryonic life and perpetuated by thymectomy 8 days after hatching. Young birds thus depleted of V beta 1+ T cells had greater than normal numbers of V beta 2+ T cells and appeared as healthy as thymectomized and untreated controls. While production of IgM and IgG antibodies was unimpaired, IgA antibody production was severely compromised in the V beta 1-depleted birds. The levels of secretory IgA in bile and lung lavage fluid were reduced 1000- to 10,000-fold and secretory IgA antibodies were not produced in response to mucosal immunization. B-cell production of IgA antibodies thus appears to require T cells expressing the V beta 1 genes, whereas T cells that express the V beta 2 genes lack this capacity.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1835793-14276257,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1835793-1720556,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1835793-2123221,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1835793-2236002,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1835793-2329276,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1835793-2425031,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1835793-2456329,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1835793-2648400,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1835793-2671008,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1835793-2964487,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1835793-3043226,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1835793-3258004,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1835793-3259182,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1835793-3259183,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1835793-3487089,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1835793-4202946,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1835793-4566557,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1835793-4577885,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1835793-4631222,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1835793-4996792,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1835793-5275387,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1835793-5914110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1835793-6185611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1835793-6230414
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD3,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin A,
http://linkedlifedata.com/resource/pubmed/chemical/Macromolecular Substances,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
88
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
10951-5
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1835793-Animals,
pubmed-meshheading:1835793-Antibodies, Monoclonal,
pubmed-meshheading:1835793-Antibody Formation,
pubmed-meshheading:1835793-Antigens, CD3,
pubmed-meshheading:1835793-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:1835793-Bile,
pubmed-meshheading:1835793-Bronchoalveolar Lavage Fluid,
pubmed-meshheading:1835793-Chickens,
pubmed-meshheading:1835793-Immunoglobulin A,
pubmed-meshheading:1835793-Immunohistochemistry,
pubmed-meshheading:1835793-Macromolecular Substances,
pubmed-meshheading:1835793-Multigene Family,
pubmed-meshheading:1835793-Organ Specificity,
pubmed-meshheading:1835793-Receptors, Antigen, T-Cell,
pubmed-meshheading:1835793-Spleen,
pubmed-meshheading:1835793-T-Lymphocytes,
pubmed-meshheading:1835793-Tears,
pubmed-meshheading:1835793-Thymectomy
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pubmed:year |
1991
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pubmed:articleTitle |
T cells expressing the V beta 1 T-cell receptor are required for IgA production in the chicken.
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pubmed:affiliation |
Institute for Animal Physiology, University of Munich, Federal Republic of Germany.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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