| pubmed-article:1835713 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1835713 | lifeskim:mentions | umls-concept:C0007600 | lld:lifeskim |
| pubmed-article:1835713 | lifeskim:mentions | umls-concept:C0018894 | lld:lifeskim |
| pubmed-article:1835713 | lifeskim:mentions | umls-concept:C0020846 | lld:lifeskim |
| pubmed-article:1835713 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:1835713 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:1835713 | lifeskim:mentions | umls-concept:C1552861 | lld:lifeskim |
| pubmed-article:1835713 | lifeskim:mentions | umls-concept:C1999230 | lld:lifeskim |
| pubmed-article:1835713 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:1835713 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:1835713 | pubmed:dateCreated | 1992-1-9 | lld:pubmed |
| pubmed-article:1835713 | pubmed:abstractText | Studies of the regulation of the IgE synthesis have been hampered by the difficulties in making lymphocytes produce IgE in vitro. Synthesis of IgE, IgG1 and IgM were investigated in a murine coculture system in which a conalbumin-specific T helper cell line of Th2 type was cultured together with nonadherent splenocytes from normal MHC-matched mice. Help provided by the antigen-stimulated T cell line induced significant IgE production (20 ng/ml), along with IgG1 (5 micrograms/ml) and IgM (250 micrograms/ml). Immunoglobulin synthesis in cultures was detectable at day 3-4 and culminated at day 7-8. IL-4 production was observed within the first 2 days of culture. The kinetics of the synthesis of the three isotypes were parallel. Stimulation of the Th2 cell line with Con A produced dose-response curves resembling those after antigen stimulation, whereas supernatant from these cells was unable to induce synthesis of IgE. The presence of interferon-gamma in the cultures, inhibited synthesis of IgE, IgM and IgG1, but this inhibition was not due to interference with the IL-4 production, which increased in the presence of high doses of interferon-gamma. | lld:pubmed |
| pubmed-article:1835713 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1835713 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1835713 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1835713 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1835713 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1835713 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1835713 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1835713 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1835713 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1835713 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1835713 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1835713 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1835713 | pubmed:issn | 0020-5915 | lld:pubmed |
| pubmed-article:1835713 | pubmed:author | pubmed-author:IshizakiSS | lld:pubmed |
| pubmed-article:1835713 | pubmed:author | pubmed-author:PoulsenL KLK | lld:pubmed |
| pubmed-article:1835713 | pubmed:author | pubmed-author:KatamuraKK | lld:pubmed |
| pubmed-article:1835713 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1835713 | pubmed:volume | 95 | lld:pubmed |
| pubmed-article:1835713 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1835713 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1835713 | pubmed:pagination | 363-8 | lld:pubmed |
| pubmed-article:1835713 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:1835713 | pubmed:meshHeading | pubmed-meshheading:1835713-... | lld:pubmed |
| pubmed-article:1835713 | pubmed:meshHeading | pubmed-meshheading:1835713-... | lld:pubmed |
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| pubmed-article:1835713 | pubmed:meshHeading | pubmed-meshheading:1835713-... | lld:pubmed |
| pubmed-article:1835713 | pubmed:meshHeading | pubmed-meshheading:1835713-... | lld:pubmed |
| pubmed-article:1835713 | pubmed:meshHeading | pubmed-meshheading:1835713-... | lld:pubmed |
| pubmed-article:1835713 | pubmed:meshHeading | pubmed-meshheading:1835713-... | lld:pubmed |
| pubmed-article:1835713 | pubmed:meshHeading | pubmed-meshheading:1835713-... | lld:pubmed |
| pubmed-article:1835713 | pubmed:meshHeading | pubmed-meshheading:1835713-... | lld:pubmed |
| pubmed-article:1835713 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1835713 | pubmed:articleTitle | IL-4-producing murine T helper cell line provides help for in vitro production of IgE. | lld:pubmed |
| pubmed-article:1835713 | pubmed:affiliation | Laboratory of Medical Allergology, National University Hospital, Copenhagen, Denmark. | lld:pubmed |
| pubmed-article:1835713 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1835713 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:1835713 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1835713 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
