Linked Life Data

1835620

Source:http://linkedlifedata.com/resource/pubmed/id/1835620

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1992-1-9
pubmed:abstractText
The relations between patient characteristics and prognosis were examined in 340 patients with advanced colorectal cancer treated with chemotherapy. Variables were tested for relation to survival and responses in univariate and multivariate analyses. Performance status (P less than 0.001), number of symptoms (P less than 0.001) and haemoglobin level (P less than 0.001) were the most important variables for survival in univariate analyses. In the multivariate analyses of survival, haemoglobin level (P less than 0.001) and disease-free interval (P less than 0.01) were the most influential variables. In addition, number of symptoms (P less than 0.01), performance status (P less than 0.05) and treatment of the primary tumour (P less than 0.05) were independently related to survival. The main independent determinant of response was haemoglobin level (P less than 0.01). Besides these pretreatment characteristics, type of chemotherapy regimen influenced both response rate and survival in multivariate analyses (P less than 0.001). We conclude that haemoglobin level, disease-free interval, symptoms and performance status are important prognostic factors in advanced colorectal cancer. The distribution of these variables may influence the results of clinical trials.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0959-8049
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1119-23
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Determinants of prognosis in advanced colorectal cancer.
pubmed:affiliation
Department of Surgery, Akademiska Sjukhuset, Uppsala, Sweden.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't