|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0006675,
umls-concept:C0010592,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0026237,
umls-concept:C0030685,
umls-concept:C0391871,
umls-concept:C0680255,
umls-concept:C1283071,
umls-concept:C1882714,
umls-concept:C1963578
|
|
pubmed:issue |
11
|
|
pubmed:dateCreated |
1991-12-31
|
|
pubmed:abstractText |
The use of the immunosuppressive drug cyclosporine A (CSA) is restricted by its nephrotoxicity. Perturbation of Ca2+ homeostasis has been implicated in chemical toxicity. Mitochondria, a key regulator of Ca2+ homeostasis, may be a target of the drug. Here we show that CSA inhibits at low concentrations the prooxidant-induced but not the sodium-induced Ca2+ release from rat kidney mitochondria. CSA does not affect Ca2+ uptake by mitochondria. Inhibition of Ca2+ release is due to inhibition of intramitochondrial enzymatic hydrolysis of NAD+ to ADP-ribose and nicotinamide. These findings suggest a very specific effect of CSA on mitochondrial Ca2+ release by which the drug interferes with cellular Ca2+ homeostasis. This is possibly the basis of CSA nephrotoxicity.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine Diphosphate Ribose,
http://linkedlifedata.com/resource/pubmed/chemical/Alloxan,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclosporine,
http://linkedlifedata.com/resource/pubmed/chemical/Glutathione,
http://linkedlifedata.com/resource/pubmed/chemical/Glutathione Disulfide,
http://linkedlifedata.com/resource/pubmed/chemical/NAD,
http://linkedlifedata.com/resource/pubmed/chemical/Niacinamide,
http://linkedlifedata.com/resource/pubmed/chemical/Oxidants,
http://linkedlifedata.com/resource/pubmed/chemical/Peroxides,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium,
http://linkedlifedata.com/resource/pubmed/chemical/tert-Butylhydroperoxide
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
0006-2952
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
6
|
|
pubmed:volume |
42
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2193-7
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:1835578-Adenosine Diphosphate Ribose,
pubmed-meshheading:1835578-Alloxan,
pubmed-meshheading:1835578-Animals,
pubmed-meshheading:1835578-Calcium,
pubmed-meshheading:1835578-Cyclosporine,
pubmed-meshheading:1835578-Female,
pubmed-meshheading:1835578-Glutathione,
pubmed-meshheading:1835578-Glutathione Disulfide,
pubmed-meshheading:1835578-Hydrolysis,
pubmed-meshheading:1835578-Kidney,
pubmed-meshheading:1835578-Mitochondria,
pubmed-meshheading:1835578-Mitochondria, Liver,
pubmed-meshheading:1835578-NAD,
pubmed-meshheading:1835578-Niacinamide,
pubmed-meshheading:1835578-Oxidants,
pubmed-meshheading:1835578-Peroxides,
pubmed-meshheading:1835578-Rats,
pubmed-meshheading:1835578-Rats, Inbred Strains,
pubmed-meshheading:1835578-Sodium,
pubmed-meshheading:1835578-tert-Butylhydroperoxide
|
|
pubmed:year |
1991
|
|
pubmed:articleTitle |
Inhibition by cyclosporine A of the prooxidant-induced but not of the sodium-induced calcium release from rat kidney mitochondria.
|
|
pubmed:affiliation |
Laboratory of Biochemistry I, Swiss Federal Institute of Technology, Zürich.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
