Source:http://linkedlifedata.com/resource/pubmed/id/18353850
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2008-5-22
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| pubmed:abstractText |
B-type natriuretic peptide is synthesized in response to increased ventricular wall stress (WS) and hypertrophy. To serially evaluate amino-terminal-pro-BNP (NT-pBNP) serum levels in patients undergoing aortic valve replacement (AVR) for severe chronic aortic regurgitation (AR), blood samples were drawn preoperatively, 15 days postoperatively, at 6- and 12-month follow-up in 25 consecutive patients. Two-dimensional echocardiography was performed concomitantly, assessing left ventricular (LV) dimensional and functional parameters, including WS. Correlations between NT-pBNP, clinical and echocardiographic data were assessed by non-parametric statistics. Median preoperative NT-pro-BNP was 276 pg/ml (IQR=85-1056), being normal or mildly increased in 20 patients, overly increased in five. The most significant correlations of preoperative NT-pBNP were with diastolic (r=0.80, P<0.001) and systolic (r=0.75, P<0.001) meridional WS and inversely with time from symptom onset (r=-0.67, P=0.001). NT-pBNP increased 15 days postoperatively (568 pg/ml, P=0.006 vs. preoperative), then decreased at 6 months (144 pg/ml, P<0.001) to remain stable at 1 year (108 pg/ml, P=0.16). Long-term follow-up NT-pBNP showed direct correlation with diastolic WS (r=0.56, P=0.02). Higher preoperative levels of NT-pBNP predicted greater magnitude of total LV mass regression at follow-up (r=-0.65, P=0.002) independent of preoperative LV mass index, showing that NT-pBNP may have a potential prognostic usefulness in adjunct to echocardiography.
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| pubmed:commentsCorrections | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/Natriuretic Peptide, Brain,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/pro-brain natriuretic peptide (1-76)
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| pubmed:status |
MEDLINE
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| pubmed:month |
May
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| pubmed:issn |
1569-9285
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
7
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
419-24; discussion 424
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| pubmed:meshHeading |
pubmed-meshheading:18353850-Adult,
pubmed-meshheading:18353850-Aortic Valve Insufficiency,
pubmed-meshheading:18353850-Biological Markers,
pubmed-meshheading:18353850-Chronic Disease,
pubmed-meshheading:18353850-Female,
pubmed-meshheading:18353850-Follow-Up Studies,
pubmed-meshheading:18353850-Heart Valve Prosthesis Implantation,
pubmed-meshheading:18353850-Humans,
pubmed-meshheading:18353850-Male,
pubmed-meshheading:18353850-Middle Aged,
pubmed-meshheading:18353850-Natriuretic Peptide, Brain,
pubmed-meshheading:18353850-Peptide Fragments,
pubmed-meshheading:18353850-Postoperative Period,
pubmed-meshheading:18353850-Predictive Value of Tests,
pubmed-meshheading:18353850-Preoperative Care,
pubmed-meshheading:18353850-Prospective Studies,
pubmed-meshheading:18353850-Severity of Illness Index,
pubmed-meshheading:18353850-Time Factors,
pubmed-meshheading:18353850-Treatment Outcome,
pubmed-meshheading:18353850-Ventricular Function, Left,
pubmed-meshheading:18353850-Ventricular Remodeling
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| pubmed:year |
2008
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| pubmed:articleTitle |
Preoperative, postoperative and 1-year follow-up N-terminal pro-B-type natriuretic peptide levels in severe chronic aortic regurgitation: correlations with echocardiographic findings.
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| pubmed:affiliation |
Department of Cardiothoracic and Respiratory Sciences, Second University of Naples, V Monaldi Hospital, Naples, Italy. aledellacorte@libero.it
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| pubmed:publicationType |
Journal Article,
Clinical Trial
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