Linked Life Data

18350154

Source:http://linkedlifedata.com/resource/pubmed/id/18350154

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2008-3-19
pubmed:abstractText
The role of the cellular protein LRP6 in anthrax toxin entry is controversial. Previous studies showed that LRP6 was important for efficient intoxication of human M2182 prostate carcinoma cells but other studies performed with cells from gene-knockout mice demonstrated no role for either LRP6 or the related LRP5 protein in anthrax toxin entry. One possible explanation for this discrepancy is that LRP6 may be important for anthrax toxin entry into human, but not mouse, cells. To test this idea we have investigated the effect of knocking down LRP6 or LRP5 expression with siRNAs in human HeLa cells. We show here that efficient knockdown of either LRP6, LRP5, or both proteins has no influence on the kinetics of anthrax lethal toxin entry or MEK1 substrate cleavage in these cells. These data argue against a human-specific role for LRP6 in anthrax toxin entry and suggest instead that involvement of this protein may be restricted to certain cell types independently of their species of origin.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/18350154-10441138, http://linkedlifedata.com/resource/pubmed/commentcorrection/18350154-11104681, http://linkedlifedata.com/resource/pubmed/commentcorrection/18350154-11207581, http://linkedlifedata.com/resource/pubmed/commentcorrection/18350154-11326092, http://linkedlifedata.com/resource/pubmed/commentcorrection/18350154-11700562, http://linkedlifedata.com/resource/pubmed/commentcorrection/18350154-12522135, http://linkedlifedata.com/resource/pubmed/commentcorrection/18350154-12551953, http://linkedlifedata.com/resource/pubmed/commentcorrection/18350154-12700348, http://linkedlifedata.com/resource/pubmed/commentcorrection/18350154-15337774, http://linkedlifedata.com/resource/pubmed/commentcorrection/18350154-15511085, http://linkedlifedata.com/resource/pubmed/commentcorrection/18350154-16051798, http://linkedlifedata.com/resource/pubmed/commentcorrection/18350154-16141341, http://linkedlifedata.com/resource/pubmed/commentcorrection/18350154-16401723, http://linkedlifedata.com/resource/pubmed/commentcorrection/18350154-16564009, http://linkedlifedata.com/resource/pubmed/commentcorrection/18350154-17335347, http://linkedlifedata.com/resource/pubmed/commentcorrection/18350154-3917427, http://linkedlifedata.com/resource/pubmed/commentcorrection/18350154-6285339, http://linkedlifedata.com/resource/pubmed/commentcorrection/18350154-7783638, http://linkedlifedata.com/resource/pubmed/commentcorrection/18350154-8051159, http://linkedlifedata.com/resource/pubmed/commentcorrection/18350154-8710889, http://linkedlifedata.com/resource/pubmed/commentcorrection/18350154-9563949, http://linkedlifedata.com/resource/pubmed/commentcorrection/18350154-9703991, http://linkedlifedata.com/resource/pubmed/commentcorrection/18350154-9704021, http://linkedlifedata.com/resource/pubmed/commentcorrection/18350154-9843379
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1932-6203
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
e1817
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Evidence against a human cell-specific role for LRP6 in anthrax toxin entry.
pubmed:affiliation
Infectious Disease Laboratory, The Salk Institute for Biological Studies, La Jolla, California, United States of America.
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural