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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2008-3-19
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pubmed:abstractText |
Individuals with Li-Fraumeni syndrome (LFS) have an inherited cancer predisposition to a diverse array of malignancies beginning early in life; survivors of one cancer have a markedly elevated risk of additional primary tumors. The underlying genetic defect in the majority of the families is a germline mutation in the TP53 tumor suppressor gene. The diversity of tumors and rarity of families have contributed to the difficulty in devising effective screening recommendations for members of LFS kindreds.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1538-3598
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pubmed:author |
pubmed-author:DigianniLisaL,
pubmed-author:DillerLisa RLR,
pubmed-author:FraumeniJoseph FJFJr,
pubmed-author:GarberJudy EJE,
pubmed-author:LiFrederick PFP,
pubmed-author:MasciariSerenaS,
pubmed-author:RastarhuyevaIrynaI,
pubmed-author:SchneiderKatherineK,
pubmed-author:SyngalSapnaS,
pubmed-author:Van den AbbeeleAnnick DAD,
pubmed-author:YapJeffreyJ
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pubmed:issnType |
Electronic
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pubmed:day |
19
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pubmed:volume |
299
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1315-9
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pubmed:meshHeading |
pubmed-meshheading:18349092-Adult,
pubmed-meshheading:18349092-Feasibility Studies,
pubmed-meshheading:18349092-Female,
pubmed-meshheading:18349092-Fluorodeoxyglucose F18,
pubmed-meshheading:18349092-Genes, p53,
pubmed-meshheading:18349092-Heterozygote,
pubmed-meshheading:18349092-Humans,
pubmed-meshheading:18349092-Li-Fraumeni Syndrome,
pubmed-meshheading:18349092-Male,
pubmed-meshheading:18349092-Mutation,
pubmed-meshheading:18349092-Neoplasms,
pubmed-meshheading:18349092-Pilot Projects,
pubmed-meshheading:18349092-Positron-Emission Tomography,
pubmed-meshheading:18349092-Radiopharmaceuticals,
pubmed-meshheading:18349092-Tomography, Spiral Computed,
pubmed-meshheading:18349092-Whole Body Imaging
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pubmed:year |
2008
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pubmed:articleTitle |
F18-fluorodeoxyglucose-positron emission tomography/computed tomography screening in Li-Fraumeni syndrome.
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pubmed:affiliation |
Division of Population Sciences, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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