Linked Life Data

18348631

Source:http://linkedlifedata.com/resource/pubmed/id/18348631

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2008-3-19
pubmed:abstractText
Quantitative structure-activity relationships (QSARs) for metal bioconcentration factors (BCF) and median acute lethal water concentrations (LC50) were developed for two species of mollusks, Perna viridis and Mytilus edulis. These endpoints were related to four metal ion characteristics, the covalent index (chi(2)(m)r) (r represents the ion radius in A), the softness index (sigma(p)), the hydrolysis constant (K(OH)) and the ionic index (Z(2)/r). The BCF and LC50 were significantly correlated to chi(m)(2)r. The coefficients of determination r(2) for the relationships with other metal descriptors were much lower. Critical body residue (CBR) QSARs were derived by multiplying the chi(2)(m)r-based BCF and LC50 regressions. The CBRs were independent of the covalent index chi(2)(m)r, as BCF and LC50 scaled to chi(2)(m)r with slope that had opposite signs. Comparison of the estimated CBRs with independent empirical values confirmed the predicted trends, but substantial deviations were noted too.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0730-7268
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
272-6
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Estimating bioconcentration factors, lethal concentrations and critical body residues of metals in the mollusks Perna viridis and Mytilus edulis using ion characteristics.
pubmed:affiliation
Department of Environmental Science, Institute for Water and Wetland Research, Radboud University Nijmegen, Nijmegen, The Netherlands.
pubmed:publicationType
Journal Article