Linked Life Data

18347410

Source:http://linkedlifedata.com/resource/pubmed/id/18347410

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2008-3-18
pubmed:abstractText
A 74-year-old male with diffuse gelatinous ascites underwent cytoreductive surgery including ileocecal resection and greater omentectomy. Pathology revealed mucinous adenocarcinoma with low-grade malignancy originating in the appendix with disseminated peritoneal adenomucinosis, which was diagnostic of pseudomyxoma peritonei. A subcutaneous reservoir was implanted intraoperatively for intraperitoneal chemotherapy initiated at the time of operation. The patient received intraperitoneal chemotherapy with weekly paclitaxel at a dose of 60 mg/m(2) for 3 weeks, followed by a 1-week rest, repeated every 4 weeks for 2 months. Subsequently, paclitaxel was given intravenously at the same dose every 2 weeks for 2 months, and then the patient was placed on oral S-1 at a dose of 100 mg/body/day, administered daily for 2 consecutive weeks, followed by a 1-week rest, repeated every 3 weeks for 9 months. The patient tolerated the chemotherapy well, developing grade 1 anemia and grade 2 neutropenia plus elevation of total bilirubin. Tumor markers, CEA and CA19-9, fell to the normal range postoperatively, and have remained stable so far. A follow-up computed tomography (CT) scan revealed small ascites only in the right pelvis 8 months later after the initial operation, and complete disappearance of ascites 17 months later. Two years later, the patient presented with ileus, and required adhesionlysis as well as partial resection of adhesive ileum. No evidence of recurrent disease was confirmed intraoperatively as a second look. To date, the patient has been free of recurrence.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0385-0684
pubmed:author
pubmed:issnType
Print
pubmed:volume
35
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
523-7
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
[A case report of pseudomyxoma peritonei demonstrating complete response after intensive therapy consisting of cytoreductive surgery and adjuvant chemotherapy with paclitaxel and S-1].
pubmed:affiliation
Dept. of Surgical Oncology, Osaka National Hospital, Japan.
pubmed:publicationType
Journal Article, English Abstract, Case Reports