Linked Life Data

18346642

Source:http://linkedlifedata.com/resource/pubmed/id/18346642

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2008-3-18
pubmed:abstractText
MicroRNAs (miRNAs) are noncoding RNA molecules of 21 to 24 nt that regulate the expression of target genes in a post-transcriptional manner. Evidence indicates that miRNAs play essential roles in embryogenesis, cell differentiation and pathogenesis of human diseases. Kidney transplantation to treat end-stage renal disease has evolved rapidly from the first successful transplantations to the current widespread use of grafts from both cadaveric and living donors. But acute rejection is still a strong risk factor for chronic rejection in recipients of renal grafts. To investigate possible mechanisms, we describe a comparison between miRNA expression profile of acute rejection and the controls. Through microarray analysis and quantitative real-time RT-PCR confirmation, we identified 20 miRNAs differently expressed in acute rejection after renal transplantation. Our data thus indicate that miRNAs were potentially involved in the pathogenesis of acute rejection, and miRNAs can help to diagnosis, treat and prevent acute rejection after renal transplantation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0966-3274
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
81-5
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Microarray analysis of MicroRNA expression in acute rejection after renal transplantation.
pubmed:affiliation
Kidney Transplantation and Hemo Purification Center, 181 Hospital of Guilin, Guangxi Province 541000, China.
pubmed:publicationType
Journal Article