Linked Life Data

18346117

Source:http://linkedlifedata.com/resource/pubmed/id/18346117

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2008-3-27
pubmed:abstractText
Candida albicans cells homozygous for the MTLa locus respond to alpha-mating pheromone by activating gene expression and triggering morphological changes, and the cells undergo a pheromone-mediated cell cycle arrest that can be influenced by nutritional conditions. Disruption of C. albicans ORF19.7105, which is the predicted homologue of the yeast FAR1 gene, blocks pheromone-mediated morphological changes, prevents pheromone-mediated cell cycle arrest, greatly compromises mating and also blocks pheromone-triggered gene induction. C. albicans ORF19.7105 is not pheromone inducible, but overexpression of this gene from the actin promoter greatly enhances pheromone-mediated cell cycle arrest, leading to clear halos in growth inhibition assays on a variety of solid media. Transcriptional profiling of the ORF19.7105-overexpressing strain has established an enhanced responsiveness of pheromone-induced genes. Thus the C. albicans FAR1 gene is a dosage-dependent regulator of the pheromone response, and is critically required for all aspects of mating process of this pathogenic fungus.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1365-2958
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
68
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
392-404
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
The role of Candida albicans FAR1 in regulation of pheromone-mediated mating, gene expression and cell cycle arrest.
pubmed:affiliation
Genetics Group, Biotechnology Research Institute, National Research Council of Canada, 6100 Royalmount Avenue, Montreal, Quebec, Canada H4P 2R2.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't