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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
1991-12-24
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pubmed:abstractText |
The autologous mixed-lymphocyte reactions (AMLR) of peripheral blood lymphocytes from 80 patients with adult periodontitis were examined. Some but not all patients showed clearly low AMLR responses; 31 of 80 subjects (39%) showing consistently low responses in AMLR (less than the mean--2 standard deviations of the healthy control group values) were designated low-AMLR patients, whereas the 42 patients (53%) who showed normal AMLR responses were designated normal-AMLR patients. However, there were no significant differences in the clinical parameters between these two groups of patients. The phenotypic analysis of T-cell fractions revealed a lower percentage of CD45RA-positive cells in CD4-positive cells (CD4+ CD45RA+ T cells) in the low-AMLR patients than those in normal-AMLR patients and healthy control subjects. No significant differences were demonstrated between the two groups in terms of the proportion of CD4-positive and CD8-positive cells in the T-cell fractions or in the expression of human leukocyte antigen DR of the monocytes and B cells in the non-T-cell fractions. In the low-AMLR patients, the allogeneic MLR was found to be normal, but the interleukin 2 production in the AMLR was found to be significantly depressed. The depressed AMLR responses and the lower percentage of CD4+ CD45RA+ T cells in the low-AMLR patients were found to be normalized following the periodontal therapy. These results might reflect changes in regulatory T-cell function induced by development of periodontal diseases.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1834575-1085685,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1834575-127826,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1834575-14121956,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1834575-14158464,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1834575-150602,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1834575-153961,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1834575-1825332,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1834575-229189,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1834575-2430045,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1834575-2524506,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1834575-2857748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1834575-2949986,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1834575-2953443,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1834575-2955047,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1834575-2960772,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1834575-2970504,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1834575-2975541,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1834575-3155770,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1834575-3156746,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1834575-3156923,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1834575-3157750,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1834575-3479062,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1834575-359708,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1834575-6215003,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1834575-6215195,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1834575-6227737,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1834575-6230184,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1834575-6235072,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1834575-6241234,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1834575-63546,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1834575-6444227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1834575-6445384,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1834575-6447164,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1834575-6448867,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1834575-6456072,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1834575-6457863,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1834575-6459343,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1834575-6572637,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1834575-6592318,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1834575-6602770
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD4,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD45,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD8,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DR Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
59
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4418-24
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1834575-Adult,
pubmed-meshheading:1834575-Antigens, CD,
pubmed-meshheading:1834575-Antigens, CD4,
pubmed-meshheading:1834575-Antigens, CD45,
pubmed-meshheading:1834575-Antigens, CD8,
pubmed-meshheading:1834575-Female,
pubmed-meshheading:1834575-HLA-DR Antigens,
pubmed-meshheading:1834575-Histocompatibility Antigens,
pubmed-meshheading:1834575-Humans,
pubmed-meshheading:1834575-Interleukin-2,
pubmed-meshheading:1834575-Lymphocyte Culture Test, Mixed,
pubmed-meshheading:1834575-Male,
pubmed-meshheading:1834575-Periodontitis,
pubmed-meshheading:1834575-Phenotype,
pubmed-meshheading:1834575-T-Lymphocytes
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pubmed:year |
1991
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pubmed:articleTitle |
Impaired autologous mixed-lymphocyte reaction of peripheral blood lymphocytes in adult periodontitis.
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pubmed:affiliation |
Department of Periodontology and Endodontology, Osaka University Faculty of Dentistry, Japan.
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pubmed:publicationType |
Journal Article
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