|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
30
|
|
pubmed:dateCreated |
2008-7-10
|
|
pubmed:abstractText |
The zebrafish has emerged as a powerful genetic model of cancer, but has been limited by the use of stable transgenic approaches to induce disease. Here, a co-injection strategy is described that capitalizes on both the numbers of embryos that can be microinjected and the ability of transgenes to segregate together and exert synergistic effects in forming tumors. Using this mosaic transgenic approach, gene pathways involved in tumor initiation and radiation sensitivity have been identified.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18345029-10720333,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18345029-10751183,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18345029-10807576,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18345029-12574629,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18345029-12764107,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18345029-14608381,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18345029-15142873,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18345029-15492244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18345029-15618471,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18345029-15630097,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18345029-15694309,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18345029-15827121,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18345029-15829520,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18345029-16166372,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18345029-16439994,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18345029-16888646,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18345029-17015828,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18345029-17510286,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18345029-17517602
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Green Fluorescent Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/KRAS protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Luminescent Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Mutant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RAG2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/ras Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/red fluorescent protein
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
1476-5594
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
10
|
|
pubmed:volume |
27
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
4242-8
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:18345029-Animals,
pubmed-meshheading:18345029-Animals, Genetically Modified,
pubmed-meshheading:18345029-Cell Transformation, Neoplastic,
pubmed-meshheading:18345029-Cleavage Stage, Ovum,
pubmed-meshheading:18345029-DNA-Binding Proteins,
pubmed-meshheading:18345029-Embryo, Nonmammalian,
pubmed-meshheading:18345029-Gene Transfer Techniques,
pubmed-meshheading:18345029-Genes, bcl-2,
pubmed-meshheading:18345029-Genes, myc,
pubmed-meshheading:18345029-Genes, p53,
pubmed-meshheading:18345029-Green Fluorescent Proteins,
pubmed-meshheading:18345029-Luminescent Proteins,
pubmed-meshheading:18345029-Microinjections,
pubmed-meshheading:18345029-Mutant Proteins,
pubmed-meshheading:18345029-Neoplasms, Radiation-Induced,
pubmed-meshheading:18345029-Nuclear Proteins,
pubmed-meshheading:18345029-Precursor T-Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:18345029-Proto-Oncogene Proteins,
pubmed-meshheading:18345029-Transgenes,
pubmed-meshheading:18345029-Zebrafish,
pubmed-meshheading:18345029-ras Proteins
|
|
pubmed:year |
2008
|
|
pubmed:articleTitle |
Co-injection strategies to modify radiation sensitivity and tumor initiation in transgenic Zebrafish.
|
|
pubmed:affiliation |
Stem Cell Program and Division of Hematology/Oncology, Children's Hospital Boston and Dana-Farber Cancer Institute, Boston, MA 2115, USA. dlangenau@enders.tch.harvard.edu
|
|
pubmed:publicationType |
Journal Article,
Evaluation Studies,
Research Support, N.I.H., Extramural
|
