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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2008-3-27
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pubmed:abstractText |
We report here that amyotrophic lateral sclerosis-linked superoxide dismutase 1 (SOD1) mutants with different biochemical characteristics disrupted the blood-spinal cord barrier in mice by reducing the levels of the tight junction proteins ZO-1, occludin and claudin-5 between endothelial cells. This resulted in microhemorrhages with release of neurotoxic hemoglobin-derived products, reductions in microcirculation and hypoperfusion. SOD1 mutant-mediated endothelial damage accumulated before motor neuron degeneration and the neurovascular inflammatory response occurred, indicating that it was a central contributor to disease initiation.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18344992-11381259,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18344992-12847526,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18344992-15808355,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18344992-15846792,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18344992-16474388,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18344992-16741123,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18344992-17015226,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18344992-17463094,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18344992-17512910,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18344992-18030339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18344992-18608097,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18344992-8209258,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18344992-9633809,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18344992-9726263,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18344992-9861044
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1097-6256
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pubmed:author |
pubmed-author:AliZarinaZ,
pubmed-author:BoilleeSeverineS,
pubmed-author:ClevelandDon WDW,
pubmed-author:DeaneRashidR,
pubmed-author:O'BanionM KerryMK,
pubmed-author:ParisiMargaretM,
pubmed-author:SagareAbhayA,
pubmed-author:ShapovalovYuriyY,
pubmed-author:StojanovicKonstantinK,
pubmed-author:ZhongZhihuiZ,
pubmed-author:ZlokovicBerislav VBV
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pubmed:issnType |
Print
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
420-2
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pubmed:dateRevised |
2011-8-1
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pubmed:meshHeading |
pubmed-meshheading:18344992-Amyotrophic Lateral Sclerosis,
pubmed-meshheading:18344992-Animals,
pubmed-meshheading:18344992-Blood-Brain Barrier,
pubmed-meshheading:18344992-Capillaries,
pubmed-meshheading:18344992-Disease Progression,
pubmed-meshheading:18344992-Endothelium, Vascular,
pubmed-meshheading:18344992-Hemorrhage,
pubmed-meshheading:18344992-Humans,
pubmed-meshheading:18344992-Isoenzymes,
pubmed-meshheading:18344992-Membrane Proteins,
pubmed-meshheading:18344992-Mice,
pubmed-meshheading:18344992-Mice, Mutant Strains,
pubmed-meshheading:18344992-Motor Neurons,
pubmed-meshheading:18344992-Nerve Degeneration,
pubmed-meshheading:18344992-Phosphoproteins,
pubmed-meshheading:18344992-Spinal Cord,
pubmed-meshheading:18344992-Superoxide Dismutase,
pubmed-meshheading:18344992-Tight Junctions
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pubmed:year |
2008
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pubmed:articleTitle |
ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration.
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pubmed:affiliation |
Center for Neurodegenerative and Vascular Brain Disorders and Department of Neurosurgery, University of Rochester Medical Center, Kornberg Medical Research Bldg., 601 Elmwood Avenue, Box 670, Rochester, New York 14642, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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