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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2008-3-17
pubmed:abstractText
Elevated superoxide formation in cardiac extracts of apolipoprotein E-knockout (apoE-KO) mice has been reported. In addition, we previously reported that hypoxia increased oxidative stress in the aortas of apoE-KO mice, although we did not examine the effect of hypoxia on the heart. The aim of this study was to investigate the effect of chronic hypoxia on the left ventricular (LV) remodeling in apoE-KO mice treated with or without an angiotensin II receptor blocker. Male apoE-KO mice (n=83) and wild-type mice (n=34) at 15 weeks of age were kept under hypoxic conditions (oxygen, 10.0+/-0.5%) and treated with olmesartan (3 mg/kg/day) or vehicle for 3 weeks. Although LV pressure was not changed, hypoxia caused hypertrophy of cardiomyocytes and increased interstitial fibrosis in the LV myocardium. Furthermore, nuclear factor-kappaB (NF-kappaB) and matrix metalloproteinase (MMP)-9 activities were increased in apoE-KO mice exposed to chronic hypoxia. Olmesartan effectively suppressed the 4-hydroxy-2-nonenal protein expression and NF-kappaB and MMP-9 activities, and preserved the fine structure of the LV myocardium without affecting the LV pressure. In conclusion, olmesartan reduced oxidative stress, and attenuated the hypoxia-induced LV remodeling, in part through the inhibition of NF-kappaB and MMP-9 activities, in apoE-KO mice.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0916-9636
pubmed:author
pubmed:issnType
Print
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1219-30
pubmed:meshHeading
pubmed-meshheading:18344628-Aldehydes, pubmed-meshheading:18344628-Angiotensin II Type 1 Receptor Blockers, pubmed-meshheading:18344628-Animals, pubmed-meshheading:18344628-Anoxia, pubmed-meshheading:18344628-Apolipoproteins E, pubmed-meshheading:18344628-Heart Ventricles, pubmed-meshheading:18344628-Hypertrophy, Left Ventricular, pubmed-meshheading:18344628-Imidazoles, pubmed-meshheading:18344628-Male, pubmed-meshheading:18344628-Matrix Metalloproteinase 9, pubmed-meshheading:18344628-Mice, pubmed-meshheading:18344628-Mice, Knockout, pubmed-meshheading:18344628-Myocytes, Cardiac, pubmed-meshheading:18344628-NADPH Oxidase, pubmed-meshheading:18344628-NF-kappa B, pubmed-meshheading:18344628-Oxidative Stress, pubmed-meshheading:18344628-Superoxides, pubmed-meshheading:18344628-Tetrazoles, pubmed-meshheading:18344628-Ventricular Remodeling
pubmed:year
2007
pubmed:articleTitle
Angiotensin II receptor blocker reduces oxidative stress and attenuates hypoxia-induced left ventricular remodeling in apolipoprotein E-knockout mice.
pubmed:affiliation
Osaka University of Pharmaceutical Sciences, Takatsuki, Japan.
pubmed:publicationType
Journal Article