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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2008-3-31
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pubmed:abstractText |
Folate-based radiopharmaceuticals can be used as imaging agents and for potential radiotherapy of folate receptor (FR)-positive malignant tissue (e.g., ovarian carcinomas). However, substantial FR expression in the kidneys results in undesired renal retention of radioactivity. Recently, we found that the preinjection of an antifolate significantly improved tumor selectivity of organometallic 99mTc-radiofolates in mice. The aim of this study was to corroborate the effect of pemetrexed with the clinically tested 111In-DTPA-folate (DTPA is diethylenetriaminepentaacetic acid) in a human ovarian cancer xenografted mouse model.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DTPA folate,
http://linkedlifedata.com/resource/pubmed/chemical/Folate Receptors, GPI-Anchored,
http://linkedlifedata.com/resource/pubmed/chemical/Folic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Folic Acid Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Glutamates,
http://linkedlifedata.com/resource/pubmed/chemical/Guanine,
http://linkedlifedata.com/resource/pubmed/chemical/Indium Radioisotopes,
http://linkedlifedata.com/resource/pubmed/chemical/Pentetic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/pemetrexed
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0161-5505
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
49
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
623-9
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:18344429-Animals,
pubmed-meshheading:18344429-Autoradiography,
pubmed-meshheading:18344429-Carrier Proteins,
pubmed-meshheading:18344429-Cell Line, Tumor,
pubmed-meshheading:18344429-Female,
pubmed-meshheading:18344429-Folate Receptors, GPI-Anchored,
pubmed-meshheading:18344429-Folic Acid,
pubmed-meshheading:18344429-Folic Acid Antagonists,
pubmed-meshheading:18344429-Glutamates,
pubmed-meshheading:18344429-Guanine,
pubmed-meshheading:18344429-Humans,
pubmed-meshheading:18344429-Indium Radioisotopes,
pubmed-meshheading:18344429-Kidney,
pubmed-meshheading:18344429-Mice,
pubmed-meshheading:18344429-Ovarian Neoplasms,
pubmed-meshheading:18344429-Pentetic Acid,
pubmed-meshheading:18344429-Receptors, Cell Surface,
pubmed-meshheading:18344429-Tomography, Emission-Computed, Single-Photon,
pubmed-meshheading:18344429-Tomography, X-Ray Computed
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pubmed:year |
2008
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pubmed:articleTitle |
Pemetrexed improves tumor selectivity of 111In-DTPA-folate in mice with folate receptor-positive ovarian cancer.
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pubmed:affiliation |
Department of Nuclear Medicine, Erasmus Medical Center, Rotterdam, The Netherlands. cristina.mueller@psi.ch
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pubmed:publicationType |
Journal Article
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