Linked Life Data

18344186

Source:http://linkedlifedata.com/resource/pubmed/id/18344186

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
15
pubmed:dateCreated
2008-6-3
pubmed:abstractText
Interest in instrumental variable (IV) analyses using genetic instruments has been growing over the past 4 years. The background, strength and weaknesses of this approach, which in the epidemiology literature has been referred to as 'Mendelian randomization', has been recently reviewed by Lawlor et al. (Statist. Med. 2007. DOI: 10.1002/sim.3034). We suggest a change in the nomenclature of 'Mendelian randomization' and discuss issues relevant to IV analysis including instrument validation, motivation of IV analysis and interpretation of IV estimates in order to motivate a more consistent and standard use of IV analysis across applications using genetic instruments.
pubmed:grant
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0277-6715
pubmed:author
pubmed:copyrightInfo
(c) 2008 John Wiley & Sons, Ltd.
pubmed:issnType
Print
pubmed:day
10
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2745-9
pubmed:dateRevised
2010-8-9
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
'Mendelian randomization' equals instrumental variable analysis with genetic instruments.
pubmed:affiliation
Department of Health Management and Policy, University of Iowa, E204 GH, Iowa City, IA 52242, USA. george-wehby@uiowa.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, N.I.H., Extramural