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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2008-5-5
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pubmed:abstractText |
Glutamate (Glu) is associated with excitotoxic cell damage. Memantine modulates the glutamate induced excitotoxicity in Alzheimer's disease (AD). No information is available as to the influence of memantine on in vivo brain glutamate levels. Hippocampal Glu levels were measured in cognitively impaired and normal individuals (n=10) before and after 6 months of memantine treatment, using three dimensional high spatial resolution (0.5 cm(3) voxels) proton magnetic resonance spectroscopy at 3 T. These measurements were also repeated in a non-treated cognitively normal group (n=6). Treatment with memantine decreased Glu/Cr (creatine) ratio in the left hippocampal region. Memantine reduced hippocampal glutamate levels, which may be consistent with its anti-excitotoxic property.
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pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/AG 22374,
http://linkedlifedata.com/resource/pubmed/grant/AG0305,
http://linkedlifedata.com/resource/pubmed/grant/AG12101,
http://linkedlifedata.com/resource/pubmed/grant/EB01015,
http://linkedlifedata.com/resource/pubmed/grant/M01 RR000096-458307,
http://linkedlifedata.com/resource/pubmed/grant/M01RR00096,
http://linkedlifedata.com/resource/pubmed/grant/NS050520,
http://linkedlifedata.com/resource/pubmed/grant/P30 AG008051-189005,
http://linkedlifedata.com/resource/pubmed/grant/P30 AG008051-199005,
http://linkedlifedata.com/resource/pubmed/grant/P30 AG08051,
http://linkedlifedata.com/resource/pubmed/grant/R01 AG012101-13,
http://linkedlifedata.com/resource/pubmed/grant/R01 AG012101-14,
http://linkedlifedata.com/resource/pubmed/grant/R01 AG012101-15,
http://linkedlifedata.com/resource/pubmed/grant/R01 AG022374-02,
http://linkedlifedata.com/resource/pubmed/grant/R01 AG022374-03,
http://linkedlifedata.com/resource/pubmed/grant/R01 AG022374-05,
http://linkedlifedata.com/resource/pubmed/grant/R01 EB001015-12,
http://linkedlifedata.com/resource/pubmed/grant/R01 EB001015-13A2,
http://linkedlifedata.com/resource/pubmed/grant/R01 NS050520-04
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18343551-10219961,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18343551-10671587,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18343551-11261801,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18343551-11924885,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18343551-12020267,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18343551-15621015,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18343551-15717010,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18343551-16034443,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18343551-16039064,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18343551-16443492,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18343551-16685718,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18343551-16767711,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18343551-16940762,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18343551-17459877,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18343551-17534907,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18343551-2547892,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18343551-8474556,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18343551-9660105,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18343551-9840826,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18343551-9860805
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0278-5846
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
32
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1005-12
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pubmed:dateRevised |
2011-1-14
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pubmed:meshHeading |
pubmed-meshheading:18343551-Adult,
pubmed-meshheading:18343551-Aged,
pubmed-meshheading:18343551-Aging,
pubmed-meshheading:18343551-Alzheimer Disease,
pubmed-meshheading:18343551-Cognition Disorders,
pubmed-meshheading:18343551-Excitatory Amino Acid Antagonists,
pubmed-meshheading:18343551-Female,
pubmed-meshheading:18343551-Glutamic Acid,
pubmed-meshheading:18343551-Hippocampus,
pubmed-meshheading:18343551-Humans,
pubmed-meshheading:18343551-Image Processing, Computer-Assisted,
pubmed-meshheading:18343551-Magnetic Resonance Imaging,
pubmed-meshheading:18343551-Magnetic Resonance Spectroscopy,
pubmed-meshheading:18343551-Male,
pubmed-meshheading:18343551-Memantine
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pubmed:year |
2008
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pubmed:articleTitle |
Memantine decreases hippocampal glutamate levels: a magnetic resonance spectroscopy study.
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pubmed:affiliation |
Center for Brain Health, Department of Psychiatry, New York University New York, NY 10016, USA. Lidia.Glodzik-Sobanska@nyumc.org
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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