Linked Life Data

18343473

Source:http://linkedlifedata.com/resource/pubmed/id/18343473

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2008-6-2
pubmed:abstractText
Diesel exhaust (DE) is a major component of urban air pollution and has been shown to increase the severity of infectious and allergic lung disease. The purpose of this study was to evaluate the effects of DE exposure on pulmonary inflammation, mediator production and antimicrobial defenses in an exposure model that had previously been shown to increase susceptibility to influenza. BALB/c mice were exposed to filtered air, or to DE diluted to yield 0.5 or 2 mg/m(3) of diesel exhaust particles (DEP) for 4 h per day for 1 or 5 days. Immediately and 18 h after one or five diesel exposures mice were euthanized to assess both immediate and delayed effects. DE exposure for 5 days at either concentration caused higher neutrophil numbers and lesion scoring compared to air controls. Intracellular adhesion molecule-1 (ICAM-1), which recruits inflammatory cells and is an entry site for rhinoviruses was increased immediately after 1 or 5 days of DE exposure. Several inflammatory and immune cytokines (TNF-alpha, MIP-2, IL-6, IFN-gamma, and IL-13) were also upregulated at various time points and concentrations. In contrast, clara cell secretory protein (CCSP), surfactant protein A (SP-A), and surfactant protein D (SP-D) which are important host defense molecules, were significantly decreased at both the message and protein level with DE exposure. We conclude that exposure to moderate and high occupational levels of DE caused an increase in lung injury and inflammation, and a decrease in host defense molecules, which could result in increased susceptibility to respiratory pathogens.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0041-008X
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
229
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
310-9
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:18343473-Air Pollutants, pubmed-meshheading:18343473-Animals, pubmed-meshheading:18343473-Cytokines, pubmed-meshheading:18343473-Female, pubmed-meshheading:18343473-Intercellular Adhesion Molecule-1, pubmed-meshheading:18343473-Lung, pubmed-meshheading:18343473-Mice, pubmed-meshheading:18343473-Mice, Inbred BALB C, pubmed-meshheading:18343473-Neutrophils, pubmed-meshheading:18343473-Occupational Exposure, pubmed-meshheading:18343473-Pneumonia, pubmed-meshheading:18343473-Pulmonary Surfactant-Associated Protein A, pubmed-meshheading:18343473-Pulmonary Surfactant-Associated Protein D, pubmed-meshheading:18343473-Respiratory Tract Infections, pubmed-meshheading:18343473-Time Factors, pubmed-meshheading:18343473-Up-Regulation, pubmed-meshheading:18343473-Uteroglobin, pubmed-meshheading:18343473-Vehicle Emissions
pubmed:year
2008
pubmed:articleTitle
Modulation of pulmonary inflammatory responses and antimicrobial defenses in mice exposed to diesel exhaust.
pubmed:affiliation
Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh, NC 27606, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, N.I.H., Extramural