Source:http://linkedlifedata.com/resource/pubmed/id/18343176
Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
2008-5-19
|
pubmed:abstractText |
The purpose was to study the effect of PCSK9 46L on cholesterol concentration and cardiovascular morbidity. By comparing 176 carriers with 6618 non-carriers identified through a cross-sectional population study (WOBASZ) we confirmed the LDL lowering effect of PCSK9 46L and demonstrated that it increases with the concentration of LDL. We noted that PCSK9 46L was associated with tendency for protection from myocardial infarction but not stroke suggesting a difference in the effect on susceptibility to these disorders.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Jun
|
pubmed:issn |
1096-7206
|
pubmed:author | |
pubmed:issnType |
Electronic
|
pubmed:volume |
94
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
259-62
|
pubmed:meshHeading |
pubmed-meshheading:18343176-Adult,
pubmed-meshheading:18343176-Aged,
pubmed-meshheading:18343176-Blood,
pubmed-meshheading:18343176-Cholesterol, LDL,
pubmed-meshheading:18343176-Cross-Sectional Studies,
pubmed-meshheading:18343176-European Continental Ancestry Group,
pubmed-meshheading:18343176-Female,
pubmed-meshheading:18343176-Genetic Predisposition to Disease,
pubmed-meshheading:18343176-Humans,
pubmed-meshheading:18343176-Male,
pubmed-meshheading:18343176-Middle Aged,
pubmed-meshheading:18343176-Myocardial Infarction,
pubmed-meshheading:18343176-Polymorphism, Genetic,
pubmed-meshheading:18343176-Serine Endopeptidases,
pubmed-meshheading:18343176-Stroke
|
pubmed:year |
2008
|
pubmed:articleTitle |
Effect of protein convertase subtilisin/kexin type 9 (PCSK9) 46L gene polymorphism on LDL cholesterol concentration in a Polish adult population.
|
pubmed:affiliation |
Department of Medical Genetics, Medical University of Warsaw, ul Oczki 1, 02-007 Warsaw, Poland.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|