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18343108
Source:
http://linkedlifedata.com/resource/pubmed/id/18343108
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rdf:type
pubmed:Citation
lifeskim:mentions
umls-concept:C0025646
,
umls-concept:C0220781
,
umls-concept:C0243077
,
umls-concept:C1883254
pubmed:issue
7
pubmed:dateCreated
2008-4-3
pubmed:abstractText
The syntheses of a new class of barbiturate-based inhibitors for human and Escherichia Coli methionine aminopeptidase-1 (MetAP-1) are described. Some of the synthesized inhibitors show selective inhibition of the human enzyme with high potency.
pubmed:grant
http://linkedlifedata.com/resource/pubmed/grant/1R01 CA113746
,
http://linkedlifedata.com/resource/pubmed/grant/R01 GM063204-01A1
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/18343108-10805534
,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18343108-11748240
,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18343108-14684302
,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18343108-15288804
,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18343108-15339172
,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18343108-15664828
,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18343108-15686921
,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18343108-16005224
,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18343108-16142902
,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18343108-16274222
,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18343108-16300729
,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18343108-16420038
,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18343108-16638869
,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18343108-16789740
,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18343108-16823043
,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18343108-16963780
,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18343108-16983082
,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18343108-17114291
,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18343108-17120228
,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18343108-9770455
pubmed:language
eng
pubmed:journal
http://linkedlifedata.com/resource/pubmed/journal/9107377
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Aminopeptidases
,
http://linkedlifedata.com/resource/pubmed/chemical/Barbiturates
,
http://linkedlifedata.com/resource/pubmed/chemical/Protease Inhibitors
,
http://linkedlifedata.com/resource/pubmed/chemical/barbituric acid
,
http://linkedlifedata.com/resource/pubmed/chemical/methionyl aminopeptidase
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1464-3405
pubmed:author
pubmed-author:HaldarManas KMK
,
pubmed-author:MallikSankuS
,
pubmed-author:ScottMichael DMD
,
pubmed-author:SrivastavaD KDK
,
pubmed-author:SuleNiteshN
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2373-6
pubmed:dateRevised
2011-3-8
pubmed:meshHeading
pubmed-meshheading:18343108-Aminopeptidases
,
pubmed-meshheading:18343108-Barbiturates
,
pubmed-meshheading:18343108-Binding Sites
,
pubmed-meshheading:18343108-Crystallography, X-Ray
,
pubmed-meshheading:18343108-Escherichia coli
,
pubmed-meshheading:18343108-Humans
,
pubmed-meshheading:18343108-Models, Chemical
,
pubmed-meshheading:18343108-Protease Inhibitors
,
pubmed-meshheading:18343108-Structure-Activity Relationship
,
pubmed-meshheading:18343108-Substrate Specificity
pubmed:year
2008
pubmed:articleTitle
Synthesis of barbiturate-based methionine aminopeptidase-1 inhibitors.
pubmed:affiliation
Department of Pharmaceutical Sciences, North Dakota State University, 1401 Albrecht Boulevard, Fargo, ND 58105, USA.
pubmed:publicationType
Journal Article
,
Research Support, U.S. Gov't, Non-P.H.S.
,
Research Support, N.I.H., Extramural