Linked Life Data

18342485

Source:http://linkedlifedata.com/resource/pubmed/id/18342485

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2008-4-18
pubmed:abstractText
A mathematical model describing the main mechanistic processes involved in keratinocyte response to chromium and nickel has been developed and compared to experimental in vitro data. Accounting for the interactions between the metal ions and the keratinocytes, the law of mass action was used to generate ordinary differential equations which predict the time evolution and ion concentration dependency of keratinocyte viability, the amount of metal associated with the keratinocytes and the release of cytokines by the keratinocytes. Good agreement between model predictions and existing experimental data of these endpoints was observed, supporting the use of this model to explore physiochemical parameters that influence the toxicological response of keratinocytes to these two metals.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0887-2333
pubmed:author
pubmed:issnType
Print
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1088-93
pubmed:dateRevised
2009-4-10
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
A mathematical model of the in vitro keratinocyte response to chromium and nickel exposure.
pubmed:affiliation
Health and Safety Laboratory, Harpur Hill, Buxton, Derbyshire SK17 9JN, UK. Susan.Franks@hsl.gov.uk <Susan.Franks@hsl.gov.uk>
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't