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rdf:type |
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lifeskim:mentions |
umls-concept:C0003855,
umls-concept:C0017262,
umls-concept:C0019004,
umls-concept:C0024429,
umls-concept:C0172537,
umls-concept:C0185117,
umls-concept:C0205263,
umls-concept:C0242184,
umls-concept:C0243077,
umls-concept:C1527362,
umls-concept:C2003941,
umls-concept:C2911684
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pubmed:issue |
2 Pt 1
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pubmed:dateCreated |
2008-3-17
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pubmed:abstractText |
It is well recognized that arteriovenous fistulas (AVFs) used for hemodialysis access have better primary patency rates with less restenosis than polytetrafluoroethylene (PTFE) grafts; however, the mechanism responsible for this is not known. Recent data suggest that hypoxia inducible factor-1 alpha (HIF-1 alpha) is associated with vascular restenosis, possibly through mechanisms that increase the production of macrophage migration inhibition factor (MIF), matrix metalloproteinase-2 (MMP-2) and MMP-9, and their inhibitors (tissue inhibitor of MMPs; TIMP). The present study tested the hypothesis that there are differences in the expression patterns of HIF-1 alpha, MIF, MMP-2, MMP-9, and TIMPs in specimens removed from patients with AVFs and PTFE grafts.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1051-0443
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
252-9
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pubmed:dateRevised |
2011-6-6
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pubmed:meshHeading |
pubmed-meshheading:18341958-Aged,
pubmed-meshheading:18341958-Arteriovenous Shunt, Surgical,
pubmed-meshheading:18341958-Blotting, Western,
pubmed-meshheading:18341958-Female,
pubmed-meshheading:18341958-Graft Occlusion, Vascular,
pubmed-meshheading:18341958-Humans,
pubmed-meshheading:18341958-Hypoxia-Inducible Factor 1,
pubmed-meshheading:18341958-Immunohistochemistry,
pubmed-meshheading:18341958-Macrophage Migration-Inhibitory Factors,
pubmed-meshheading:18341958-Male,
pubmed-meshheading:18341958-Matrix Metalloproteinase 2,
pubmed-meshheading:18341958-Matrix Metalloproteinase 9,
pubmed-meshheading:18341958-Middle Aged,
pubmed-meshheading:18341958-Polytetrafluoroethylene,
pubmed-meshheading:18341958-Renal Dialysis
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pubmed:year |
2008
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pubmed:articleTitle |
Expression of hypoxia inducible factor-1 alpha, macrophage migration inhibition factor, matrix metalloproteinase-2 and -9, and their inhibitors in hemodialysis grafts and arteriovenous fistulas.
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pubmed:affiliation |
Department of Radiology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA. misra.sanjay@mayo.edu <misra.sanjay@mayo.edu>
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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