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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2008-4-29
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pubmed:abstractText |
Taking into account the antioxidant properties of zinc, it is difficult to explain the beneficial effects of HMG-CoA reductase inhibitors in the context of a well-known decreased zinc status. Therefore, intracellular zinc homeostasis was studied in patients with low-grade carotid atherosclerosis under treatment with HMG-CoA reductase inhibitors using a custom microarray-based approach developed by pooling information across microarray studies. Experimental data unravel an active zinc signaling in PBMC from low-grade atherosclerotic patients under lipid reduction therapy, suggesting that monitoring intracellular zinc status could be a key factor for an optimal strategy and targeting a level of intervention.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1549-1684
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pubmed:author |
pubmed-author:CiprianoCatiaC,
pubmed-author:CostarelliLauraL,
pubmed-author:EmanuelliMonicaM,
pubmed-author:GiacconiRobertinaR,
pubmed-author:GobbiBeatriceB,
pubmed-author:MalavoltaMarcoM,
pubmed-author:MocchegianiEugenioE,
pubmed-author:MutiElisaE,
pubmed-author:ProvincialiLeandroL,
pubmed-author:SartiniDavideD,
pubmed-author:SilvestriniMauroM
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pubmed:issnType |
Print
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
287-91
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pubmed:meshHeading |
pubmed-meshheading:18341426-Aged,
pubmed-meshheading:18341426-Aged, 80 and over,
pubmed-meshheading:18341426-Aging,
pubmed-meshheading:18341426-Atherosclerosis,
pubmed-meshheading:18341426-Case-Control Studies,
pubmed-meshheading:18341426-Female,
pubmed-meshheading:18341426-Gene Expression Profiling,
pubmed-meshheading:18341426-Gene Expression Regulation,
pubmed-meshheading:18341426-Homeostasis,
pubmed-meshheading:18341426-Humans,
pubmed-meshheading:18341426-Hydroxymethylglutaryl-CoA Reductase Inhibitors,
pubmed-meshheading:18341426-Male,
pubmed-meshheading:18341426-Middle Aged,
pubmed-meshheading:18341426-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:18341426-Reproducibility of Results,
pubmed-meshheading:18341426-Zinc
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pubmed:year |
2008
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pubmed:articleTitle |
Modulation of genes involved in zinc homeostasis in old low-grade atherosclerotic patients under effects of HMG-CoA reductase inhibitors.
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pubmed:affiliation |
Immunology Center, Section of Nutrition, Immunity and Ageing, Research Department, INRCA, Ancona, Italy. lauracostarelli@hotmail.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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