| pubmed-article:18337576 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18337576 | lifeskim:mentions | umls-concept:C0220847 | lld:lifeskim |
| pubmed-article:18337576 | lifeskim:mentions | umls-concept:C0042769 | lld:lifeskim |
| pubmed-article:18337576 | lifeskim:mentions | umls-concept:C0025260 | lld:lifeskim |
| pubmed-article:18337576 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:18337576 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:18337576 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:18337576 | lifeskim:mentions | umls-concept:C0205359 | lld:lifeskim |
| pubmed-article:18337576 | lifeskim:mentions | umls-concept:C0449774 | lld:lifeskim |
| pubmed-article:18337576 | lifeskim:mentions | umls-concept:C0439828 | lld:lifeskim |
| pubmed-article:18337576 | lifeskim:mentions | umls-concept:C2699488 | lld:lifeskim |
| pubmed-article:18337576 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:18337576 | lifeskim:mentions | umls-concept:C2728259 | lld:lifeskim |
| pubmed-article:18337576 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:18337576 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:18337576 | pubmed:dateCreated | 2008-4-25 | lld:pubmed |
| pubmed-article:18337576 | pubmed:abstractText | The inhibitory receptor programmed death-1 (PD-1) is present on CD8(+) T cells in chronic hepatitis C virus (HCV), but expression patterns in spontaneously resolving infections are incompletely characterized. Here we report that PD-1 was usually absent on memory CD8(+) T cells from chimpanzees with resolved infections, but sustained low-level expression was sometimes observed in the absence of apparent virus replication. PD-1-positive memory T cells expanded and displayed antiviral activity upon reinfection with HCV, indicating conserved function. This animal model should facilitate studies of whether PD-1 differentially influences effector and memory T-cell function in resolved versus persistent human infections. | lld:pubmed |
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| pubmed-article:18337576 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18337576 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18337576 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18337576 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18337576 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18337576 | pubmed:month | May | lld:pubmed |
| pubmed-article:18337576 | pubmed:issn | 1098-5514 | lld:pubmed |
| pubmed-article:18337576 | pubmed:author | pubmed-author:FreemanGordon... | lld:pubmed |
| pubmed-article:18337576 | pubmed:author | pubmed-author:BowenDavid... | lld:pubmed |
| pubmed-article:18337576 | pubmed:author | pubmed-author:Wucherpfennig... | lld:pubmed |
| pubmed-article:18337576 | pubmed:author | pubmed-author:HoughtonMicha... | lld:pubmed |
| pubmed-article:18337576 | pubmed:author | pubmed-author:CawthonAndrew... | lld:pubmed |
| pubmed-article:18337576 | pubmed:author | pubmed-author:FullerMichael... | lld:pubmed |
| pubmed-article:18337576 | pubmed:author | pubmed-author:GrakouiArashA | lld:pubmed |
| pubmed-article:18337576 | pubmed:author | pubmed-author:WalkerChristo... | lld:pubmed |
| pubmed-article:18337576 | pubmed:author | pubmed-author:ShoukryNaglaa... | lld:pubmed |
| pubmed-article:18337576 | pubmed:author | pubmed-author:BraskyKathlee... | lld:pubmed |
| pubmed-article:18337576 | pubmed:author | pubmed-author:SethNilufer... | lld:pubmed |
| pubmed-article:18337576 | pubmed:author | pubmed-author:DongChristine... | lld:pubmed |
| pubmed-article:18337576 | pubmed:author | pubmed-author:Hasselschwert... | lld:pubmed |
| pubmed-article:18337576 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18337576 | pubmed:volume | 82 | lld:pubmed |
| pubmed-article:18337576 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18337576 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18337576 | pubmed:pagination | 5109-14 | lld:pubmed |
| pubmed-article:18337576 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:18337576 | pubmed:meshHeading | pubmed-meshheading:18337576... | lld:pubmed |
| pubmed-article:18337576 | pubmed:meshHeading | pubmed-meshheading:18337576... | lld:pubmed |
| pubmed-article:18337576 | pubmed:meshHeading | pubmed-meshheading:18337576... | lld:pubmed |
| pubmed-article:18337576 | pubmed:meshHeading | pubmed-meshheading:18337576... | lld:pubmed |
| pubmed-article:18337576 | pubmed:meshHeading | pubmed-meshheading:18337576... | lld:pubmed |
| pubmed-article:18337576 | pubmed:meshHeading | pubmed-meshheading:18337576... | lld:pubmed |
| pubmed-article:18337576 | pubmed:meshHeading | pubmed-meshheading:18337576... | lld:pubmed |
| pubmed-article:18337576 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18337576 | pubmed:articleTitle | Variable patterns of programmed death-1 expression on fully functional memory T cells after spontaneous resolution of hepatitis C virus infection. | lld:pubmed |
| pubmed-article:18337576 | pubmed:affiliation | Center for Vaccines and Immunity, The Research Institute at Nationwide Children's Hospital, 700 Childrens Dr., Columbus, OH 43205, USA. | lld:pubmed |
| pubmed-article:18337576 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18337576 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:18337576 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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