|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0025260,
umls-concept:C0039194,
umls-concept:C0042769,
umls-concept:C0185117,
umls-concept:C0205245,
umls-concept:C0205359,
umls-concept:C0220847,
umls-concept:C0439828,
umls-concept:C0449774,
umls-concept:C2699488,
umls-concept:C2728259,
umls-concept:C2911684
|
|
pubmed:issue |
10
|
|
pubmed:dateCreated |
2008-4-25
|
|
pubmed:abstractText |
The inhibitory receptor programmed death-1 (PD-1) is present on CD8(+) T cells in chronic hepatitis C virus (HCV), but expression patterns in spontaneously resolving infections are incompletely characterized. Here we report that PD-1 was usually absent on memory CD8(+) T cells from chimpanzees with resolved infections, but sustained low-level expression was sometimes observed in the absence of apparent virus replication. PD-1-positive memory T cells expanded and displayed antiviral activity upon reinfection with HCV, indicating conserved function. This animal model should facilitate studies of whether PD-1 differentially influences effector and memory T-cell function in resolved versus persistent human infections.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18337576-11356962,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18337576-11927944,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18337576-12218168,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18337576-12438568,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18337576-12810686,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18337576-12975468,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18337576-14578870,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18337576-14625547,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18337576-15140950,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18337576-15879083,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18337576-15956369,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18337576-16107834,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18337576-16175596,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18337576-16382236,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18337576-16917489,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18337576-16921384,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18337576-16954372,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18337576-16956940,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18337576-17182670,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18337576-17326153,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18337576-17567698
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
1098-5514
|
|
pubmed:author |
pubmed-author:BowenDavid GDG,
pubmed-author:BraskyKathleen MKM,
pubmed-author:CawthonAndrew GAG,
pubmed-author:DongChristineC,
pubmed-author:FreemanGordon JGJ,
pubmed-author:FullerMichael JMJ,
pubmed-author:GrakouiArashA,
pubmed-author:HasselschwertDana LDL,
pubmed-author:HoughtonMichaelM,
pubmed-author:SethNilufer PNP,
pubmed-author:ShoukryNaglaa HNH,
pubmed-author:WalkerChristopher MCM,
pubmed-author:WucherpfennigKai WKW
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
82
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
5109-14
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
|
|
pubmed:year |
2008
|
|
pubmed:articleTitle |
Variable patterns of programmed death-1 expression on fully functional memory T cells after spontaneous resolution of hepatitis C virus infection.
|
|
pubmed:affiliation |
Center for Vaccines and Immunity, The Research Institute at Nationwide Children's Hospital, 700 Childrens Dr., Columbus, OH 43205, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|
