Linked Life Data

18337117

Source:http://linkedlifedata.com/resource/pubmed/id/18337117

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2008-4-2
pubmed:abstractText
Liver cirrhosis develops only in a minority of heavy drinkers. Genetic factors may account for some variation in the progression of fibrosis in alcoholic liver disease (ALD). Transforming growth factor beta 1 (TGFbeta1) is a key profibrogenic cytokine in fibrosis and its gene contains several polymorphic sites. A single nucleotide polymorphism at codon 25 has been suggested to affect fibrosis progression in patients with chronic hepatitis C virus infection, fatty liver disease, and hereditary hemochromatosis. Its contribution to the progression of ALD has not been investigated sufficiently so far.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1096-0023
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
42
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
18-23
pubmed:meshHeading
pubmed-meshheading:18337117-Adult, pubmed-meshheading:18337117-Alcohol Drinking, pubmed-meshheading:18337117-Arginine, pubmed-meshheading:18337117-Codon, pubmed-meshheading:18337117-DNA Mutational Analysis, pubmed-meshheading:18337117-Female, pubmed-meshheading:18337117-Gene Frequency, pubmed-meshheading:18337117-Genetic Predisposition to Disease, pubmed-meshheading:18337117-Genotype, pubmed-meshheading:18337117-Humans, pubmed-meshheading:18337117-Liver Cirrhosis, Alcoholic, pubmed-meshheading:18337117-Liver Diseases, Alcoholic, pubmed-meshheading:18337117-Liver Transplantation, pubmed-meshheading:18337117-Male, pubmed-meshheading:18337117-Middle Aged, pubmed-meshheading:18337117-Multivariate Analysis, pubmed-meshheading:18337117-Polymorphism, Genetic, pubmed-meshheading:18337117-Proline, pubmed-meshheading:18337117-Transforming Growth Factor beta1
pubmed:year
2008
pubmed:articleTitle
Evaluation of the transforming growth factor beta1 codon 25 (Arg-->Pro) polymorphism in alcoholic liver disease.
pubmed:affiliation
Department of Medicine, University of California, San Diego, Leichtag Building, Room 349-I, 9500 Gilman Drive, #0702, La Jolla, CA 92093-0702, USA. coesterr@ucsd.edu
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't