Source:http://linkedlifedata.com/resource/pubmed/id/18336947
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2008-5-13
|
| pubmed:abstractText |
Diabetic nephropathy is a major cause of lower-limb amputation. We enrolled 250 type 2 diabetic patients without apparent occlusive peripheral arterial disease (ankle-brachial indices >0.9) and 40 age-matched nondiabetic subjects consecutively admitted to our hospital. Flow volume and resistive index (RI), an index of vascular resistance, at the popliteal artery were evaluated using gated two-dimensional cine-mode phase-contrast magnetic resonance imaging. Brachial-ankle pulse wave velocity (baPWV) was measured as an index of arterial distensibility. Flow volume was negatively correlated with both baPWV (p=0.0009) and RI (p<0.0001) among the patients. When the patients were grouped into four subgroups with or without albuminuria and renal insufficiency according to the levels of urinary albumin excretion rate (>or=20 or <20microg/min) and estimated glomerular filtration rate (eGFR) (<60 or >or=60ml/min/1.73m(2)), albuminuric patients with renal insufficiency (n=30) showed the lowest flow volume (p=0.0078) and the highest baPWV (p=0.0006) and RI (p=0.0274) among the groups. Simple linear regression analyses demonstrated that eGFR correlated positively with flow volume (p=0.0020) and negatively with baPWV (p=0.0258) and RI (p=0.0029) in patients with albuminuria (n=92), but not with normoalbuminuria (n=158). Impaired peripheral circulation in lower-leg arteries associates with nephropathy in diabetic patients even though they have normal ankle-brachial indices.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
1872-8227
|
| pubmed:author |
pubmed-author:FujimotoKazumaK,
pubmed-author:HisatomiAkitakaA,
pubmed-author:InubushiToshiroT,
pubmed-author:ItoIsamuI,
pubmed-author:KashiwagiAtsunoriA,
pubmed-author:MaegawaHiroshiH,
pubmed-author:MorikawaShigehiroS,
pubmed-author:NishioYoshihikoY,
pubmed-author:SakaguchiMasayoshiM,
pubmed-author:SuzukiEijiE,
pubmed-author:TakedaJunJ,
pubmed-author:UzuTakashiT,
pubmed-author:YoshimuraToruT
|
| pubmed:issnType |
Electronic
|
| pubmed:volume |
80
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
416-23
|
| pubmed:meshHeading |
pubmed-meshheading:18336947-Aged,
pubmed-meshheading:18336947-Arterial Occlusive Diseases,
pubmed-meshheading:18336947-Blood Flow Velocity,
pubmed-meshheading:18336947-Blood Pressure,
pubmed-meshheading:18336947-Brachial Artery,
pubmed-meshheading:18336947-Diabetes Mellitus, Type 2,
pubmed-meshheading:18336947-Diabetic Angiopathies,
pubmed-meshheading:18336947-Diabetic Nephropathies,
pubmed-meshheading:18336947-Diastole,
pubmed-meshheading:18336947-Female,
pubmed-meshheading:18336947-Hemoglobin A, Glycosylated,
pubmed-meshheading:18336947-Humans,
pubmed-meshheading:18336947-Leg,
pubmed-meshheading:18336947-Male,
pubmed-meshheading:18336947-Middle Aged,
pubmed-meshheading:18336947-Peripheral Vascular Diseases,
pubmed-meshheading:18336947-Vascular Resistance
|
| pubmed:year |
2008
|
| pubmed:articleTitle |
Impaired peripheral circulation in lower-leg arteries caused by higher arterial stiffness and greater vascular resistance associates with nephropathy in type 2 diabetic patients with normal ankle-brachial indices.
|
| pubmed:affiliation |
Department of Medicine, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga 520-2192, Japan.
|
| pubmed:publicationType |
Journal Article
|