Linked Life Data

18336241

Source:http://linkedlifedata.com/resource/pubmed/id/18336241

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2008-3-13
pubmed:abstractText
Vascular calcification is associated with increased cardiovascular morbidity and mortality and has long been associated with advanced atherosclerotic lesions. While vascular calcification is considered a surrogate marker for atherosclerosis, the mechanisms that link the two are poorly understood. The consensus of recent research is that active regulatory processes govern vascular calcification, and much focus has been placed on elucidating the phenomenon of atherosclerotic calcification. Building upon extensive in vitro work and the previous development of atherosclerotic murine models, several groups have developed murine models of atherosclerotic calcification. From imposing chronic renal failure to developing double-knockout mice, this recent work has provided insight into the pathophysiology of mineralized matrix formation in atherosclerotic lesions, as well as development of potential therapies to prevent or inhibit progression of calcified plaque. The aim is to briefly review current understanding of the molecular basis for atherosclerotic calcification and to discuss some murine models that may be useful in advancing knowledge of its mechanisms.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1873-5592
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
224-8
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Murine models of atherosclerotic calcification.
pubmed:affiliation
Department of Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
pubmed:publicationType
Journal Article, Review