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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
1991-11-21
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pubmed:abstractText |
The responsiveness to IL-4 with and without costimulation with anti-IgM antibodies or phorbolester was studied in 35 cases of low grade non-Hodgkin lymphoma by analyzing enhancement of CD23 and HLA class II expression. The predominant phenotype responds directly to IL-4. Separate differentiation states can be distinguished according to coordinate or differential upregulation of CD23 and HLA class II molecules by IL-4 alone, and differences in responsiveness to anti-IgM antibodies. A particular subgroup of B-lymphoma cells defines a separate stage of B-cell differentiation. They fail to express high affinity binding sites for IL-4 and accordingly do not respond to IL-4-mediated signals. Cross-linking membrane IgM receptors or direct activation of protein kinase C via phorbolester induces IL-4 receptor expression and subsequent IL-4 reactivity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Anti-Idiotypic,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class II,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin M,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Fc,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, IgE,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-4,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Mitogen,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Tetradecanoylphorbol Acetate
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pubmed:status |
MEDLINE
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pubmed:issn |
0145-2126
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
911-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1833595-Antibodies, Anti-Idiotypic,
pubmed-meshheading:1833595-Antibodies, Monoclonal,
pubmed-meshheading:1833595-Antigens, CD,
pubmed-meshheading:1833595-Antigens, Differentiation, B-Lymphocyte,
pubmed-meshheading:1833595-B-Lymphocytes,
pubmed-meshheading:1833595-Cell Differentiation,
pubmed-meshheading:1833595-Histocompatibility Antigens Class II,
pubmed-meshheading:1833595-Humans,
pubmed-meshheading:1833595-Immunoglobulin M,
pubmed-meshheading:1833595-Interleukin-4,
pubmed-meshheading:1833595-Lymphoma, B-Cell,
pubmed-meshheading:1833595-Receptors, Fc,
pubmed-meshheading:1833595-Receptors, IgE,
pubmed-meshheading:1833595-Receptors, Interleukin-4,
pubmed-meshheading:1833595-Receptors, Mitogen,
pubmed-meshheading:1833595-Recombinant Proteins,
pubmed-meshheading:1833595-Tetradecanoylphorbol Acetate,
pubmed-meshheading:1833595-Tumor Cells, Cultured
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pubmed:year |
1991
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pubmed:articleTitle |
Regulation of IL-4 responsiveness in lymphoma B cells.
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pubmed:affiliation |
Medizinische Poliklinik, University of Würzburg, F.R.G.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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