Source:http://linkedlifedata.com/resource/pubmed/id/18334282
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2008-5-6
|
| pubmed:abstractText |
LAPTM4B was proven to overexpress in hepatocellular carcinoma and relate to differentiation. We immunohistochemically investigated the expression and potential clinicopathological and prognostic significance of LAPTM4B encoded protein, LAPTM4B-35, in extrahepatic cholangiocarcinoma (EHCC) for specimens from consecutive 81 patients. LAPTM4B-35 staining was positive in cancer tissues from 59 patients (72.8%), including 12 with score 1, 22 with score 2 and 25 with score 3. No positive staining was found in non-cancer epithelia. The staining score in cancer tissues was not only significantly associated with TNM staging, histological grade, perineural and lymph node invasion (P<0.05), but also of comprehensive prognostic implications, including integrated estimation with CA19-9. These data established that LAPTM4B-35 positively expressed in a great portion of EHCC and might be a novel molecular maker of progression, invasiveness and poor prognosis.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0304-3835
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
18
|
| pubmed:volume |
264
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
209-17
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| pubmed:dateRevised |
2010-11-18
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| pubmed:meshHeading |
pubmed-meshheading:18334282-Adult,
pubmed-meshheading:18334282-Aged,
pubmed-meshheading:18334282-Aged, 80 and over,
pubmed-meshheading:18334282-Bile Duct Neoplasms,
pubmed-meshheading:18334282-Bile Ducts, Extrahepatic,
pubmed-meshheading:18334282-Cholangiocarcinoma,
pubmed-meshheading:18334282-Disease Progression,
pubmed-meshheading:18334282-Disease-Free Survival,
pubmed-meshheading:18334282-Female,
pubmed-meshheading:18334282-Humans,
pubmed-meshheading:18334282-Immunohistochemistry,
pubmed-meshheading:18334282-Kaplan-Meier Estimate,
pubmed-meshheading:18334282-Male,
pubmed-meshheading:18334282-Membrane Proteins,
pubmed-meshheading:18334282-Middle Aged,
pubmed-meshheading:18334282-Neoplasm Invasiveness,
pubmed-meshheading:18334282-Neoplasm Staging,
pubmed-meshheading:18334282-Oncogene Proteins,
pubmed-meshheading:18334282-Prognosis,
pubmed-meshheading:18334282-Tumor Markers, Biological
|
| pubmed:year |
2008
|
| pubmed:articleTitle |
Expression of LAPTM4B-35: a novel marker of progression, invasiveness and poor prognosis of extrahepatic cholangiocarcinoma.
|
| pubmed:affiliation |
Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing 100032, China. lizhou02@hotmail.com
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|