Linked Life Data

18333854

Source:http://linkedlifedata.com/resource/pubmed/id/18333854

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2008-3-12
pubmed:abstractText
Brain-derived neurotrophic factor (BDNF) is a growth factor belonging to the family of neurotrophins. Neurotrophins exert their effects by binding to corresponding receptors, which are formed by the tyrosine receptor kinases TrkA, TrkB and TrkC, and the low-affinity p75NTR receptor. The role of neurotrophins in the biology of male genital organs is far from clear. In particular, little is known about the influence of sex hormones on the expression of neurotrophin receptors. In the present study, using immunohistochemistry, we investigated the distribution of TrkB and p75NTR in the vas deferens and accessory male genital glands in normal and castrated rats. In normal rats, both TrkB and p75NTR immunoreactivities were localized in the epithelial layer of the vas deferens and prostate gland. The nerves were immunoreactive in all the examined organs. Castration induced the loss of both TrkB and p75NTR immunoreactivities in the epithelial layer. On the contrary, both receptors persisted or, as in the case of p75NTR, increased in the nerves after castration. These results show that receptors that bind BDNF are expressed in the internal male genital organs of the rat and that their expression is differently regulated by androgen hormones. It can be hypothesized that BDNF, via interacting with p75NTR, has a role in the castration-induced regression of the sympathetic nerves.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1439-0264
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
37
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
118-25
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Effects of castration on the expression of TrkB and p75NTR in the vas deferens and male accessory genital glands of the rat.
pubmed:affiliation
Department of Structure, Functions and Biological Technologies, University of Naples Federico II, Via Veterinaria 1, I-80137, Naples, Italy. mirabell@unina.it
pubmed:publicationType
Journal Article