Linked Life Data

18332612

Source:http://linkedlifedata.com/resource/pubmed/id/18332612

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2008-3-11
pubmed:abstractText
Most invasive fungal infections such as candidemia are frequent in patients with hematologic malignancies. We measured cytokines/chemokines (IL-6, IL-8, monocytic chemoattractant protein 1, RANTES and epithelial neutrophil-activating peptide 78), soluble molecules (sFas, sE-selectin and soluble vascular cell adhesion molecule 1) and platelet activation markers (soluble CD40 ligand, sP-selectin and platelet-derived microparticles) in patients with hematologic malignancies under prophylactic treatment with an antifungal drug (fosfluconazole). We classified patients into 2 groups by the level of beta-D-glucan. The level of C-reactive protein was higher in the high beta-D-glucan group (>5 pg/ml) than in the low beta-D-glucan group. However, there were no differences in the levels of other parameters (peripheral blood cells, glutamic-oxaloacetic transaminase, glutamic-pyruvic transaminase, lactate dehydrogenase, blood urea nitrogen and creatinine). Patients in the high beta-D-glucan group exhibited a significant elevation of several chemokines, soluble molecules and platelet activation markers compared with those in the low beta-D-glucan group, but the levels of IL-8, monocytic chemoattractant protein 1 and sFas did not differ significantly. The levels of C-reactive protein and IL-6 increased significantly after 1 or 2 weeks on fosfluconazole in both groups. In contrast, the high beta-D-glucan group exhibited a significant decrease in chemokines, soluble markers and platelet-derived microparticles compared with the low beta-D-glucan group after treatment with fosfluconazole, although the patients in the low beta-D-glucan group exhibited no significant changes. Furthermore, the levels of RANTES, epithelial neutrophil-activating peptide 78, soluble vascular cell adhesion molecule 1 and sE-selectin correlated positively with platelet-derived microparticles in the high beta-D-glucan group. These findings suggest that fungal infection may modulate the vascular events in which some platelet-related chemokines are involved.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1424-8840
pubmed:author
pubmed:copyrightInfo
Copyright 2008 S. Karger AG, Basel.
pubmed:issnType
Electronic
pubmed:volume
36
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
32-9
pubmed:meshHeading
pubmed-meshheading:18332612-Adult, pubmed-meshheading:18332612-Aged, pubmed-meshheading:18332612-Aged, 80 and over, pubmed-meshheading:18332612-Antifungal Agents, pubmed-meshheading:18332612-Antineoplastic Combined Chemotherapy Protocols, pubmed-meshheading:18332612-Biological Markers, pubmed-meshheading:18332612-Candidiasis, pubmed-meshheading:18332612-Cell Adhesion Molecules, pubmed-meshheading:18332612-Chemokines, pubmed-meshheading:18332612-Female, pubmed-meshheading:18332612-Fluconazole, pubmed-meshheading:18332612-Fungemia, pubmed-meshheading:18332612-Hematologic Neoplasms, pubmed-meshheading:18332612-Humans, pubmed-meshheading:18332612-Male, pubmed-meshheading:18332612-Middle Aged, pubmed-meshheading:18332612-Neutropenia, pubmed-meshheading:18332612-Phosphoric Acid Esters, pubmed-meshheading:18332612-Platelet Activation, pubmed-meshheading:18332612-Prodrugs, pubmed-meshheading:18332612-beta-Glucans
pubmed:year
2007
pubmed:articleTitle
Elevation of activated platelet-dependent chemokines and soluble cell adhesion molecules in patients with hematologic malignancies and high levels of beta-D-glucan.
pubmed:affiliation
Division of Hematology, Kishiwada City Hospital, Kishiwada, Japan. shosaku-n@mbp.ocn.ne.jp
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't